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TranscriptomicsHigh throughput targeted RNA sequencing on RPTEC/TERT1 cell line exposed to multiple concentration levels of cyclosporine A at various different time points
This experiment was carried out to investigate the time dynamics of the proximal tubule cells upon the exposure of cyclosporine A in multiple severity scenario by varying the concentration. The RPTEC/TERT1 cells which are immortalized human proximal tubule cells were differentiated for 14 days to re...
ORGANISM(S): Homo sapiens 
2023-06-10 | E-MTAB-11553 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Responses of Laser Capture Microdissected Nephrons from Rat Kidneys Exposed to Single administration of 5 mg/kg Cisplatin : 29 days study - first technical replicate of the RNA sequencing
The data contains the transcriptomic responses of the nephron segments (CPT : cortical proximal tubules and PPT : Perimedular proximal tubules) of the rat kidneys exposed to single administration of cisplatin i.v. 5 mg/kg for 29 days (1, 3, 5, 8, 10, 12, 15, 20, 28 days of collection times). The kid...
ORGANISM(S): Rattus norvegicus 
2025-07-15 | E-MTAB-11969 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Responses of Laser Capture Microdissected Nephrons from Rat Kidneys Exposed to Single administration of Cisplatin at Multiple Dose Level for 72 Hours
The data contains the transcriptomic responses of the nephron segments (GM : glomerulus, CPT : cortical proximal tubules, and PPT : Perimedular proximal tubules) of the rat kidneys exposed to single administration of cisplatin i.v. (0, 1, 2.5, 5, 7.5 mg/kg) for 72 hours. The kidneys were fixed with ...
ORGANISM(S): Rattus norvegicus 
2025-03-31 | E-MTAB-11934 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Responses of Laser Capture Microdissected Nephrons from Rat Kidneys Exposed to Single administration of 5 mg/kg Cisplatin: 29 days study - second technical replicate of the RNA sequencing
The data contains the transcriptomic responses of the nephron segments (CPT: cortical proximal tubules and PPT: perimedular proximal tubules) of the rat kidneys exposed to single administration of cisplatin i.v. 5 mg/kg for 29 days (1, 3, 5, 8, 10, 12, 15, 20, 28 days of collection times). The kidne...
ORGANISM(S): Rattus norvegicus 
2025-07-15 | E-MTAB-12016 | biostudies-arrayexpress
TranscriptomicsHigh throughput targeted RNA sequencing on HepG2 cell line exposed to multiple concentration levels of drug induced liver injury (DILI) compounds at various different time points_part1
This experiment was carried out to investigate the responses of the human liver model (HepG2) cells upon the exposure of various DILI compounds in multiple severity scenarios by varying the concentration. The cells were seeded in 384 well plate format containing 8000 cell per well with 2 days of res...
ORGANISM(S): Homo sapiens 
2024-02-05 | E-MTAB-11555 | biostudies-arrayexpress
TranscriptomicsHigh throughput targeted RNA sequencing on HepG2 cell line exposed to multiple concentration levels of drug induced liver injury (DILI) compounds at various different time points_part2
This experiment was carried out to investigate the responses of the human liver model (HepG2) cells upon the exposure of various DILI compounds (second set) in multiple severity scenarios by varying the concentration. The cells were seeded in 384 well plate format containing 8000 cell per well with ...
ORGANISM(S): Homo sapiens 
2024-03-23 | E-MTAB-11578 | biostudies-arrayexpress
TranscriptomicsHigh throughput targeted RNA sequencing on RPTEC/TERT1 cell line exposed to multiple concentration levels at various different time points
This experiment was carried out to investigate the time dynamics of the proximal tubule cells upon the exposure of cisplatin in multiple severity scenario by varying the concentration. The RPTEC/TERT1 cells which are immortalized human proximal tubule cells were differentiated for 14 days to reach t...
ORGANISM(S): Homo sapiens 
2026-08-31 | E-MTAB-11374 | biostudies-arrayexpress
ModelsWijayaTrairatphisan2021 - Logic-ODE model of stress signaling in DILI
We established a comprehensive temporal dynamic response profile of a large set of BAC-GFP HepG2 cell lines representing the following components of stress signaling: i) unfolded protein response (UPR) [ATF4, XBP1, BIP and CHOP]; ii) oxidative stress [NRF2, SRXN1, HMOX1]; iii) DNA damage [P53, P21, ...
2022-08-02 | MODEL2206070001 | BioModels
TransQST 
TranscriptomicsGene expression analysis of cultured rat primary proximal tubular cells (PTC) after isolation and differentiation
The aim of this study is to evaluate the transcripitomics changes during dedifferentiation up to 7 days in a transwell system of rat primary proximal tubular cell (PTC) cultures isolated from rat kidneys. Samples were taken from freshly isolated PTC (0 days) and at timeponts during PTC differentiati...
ORGANISM(S): Rattus norvegicus 
2024-06-30 | E-MTAB-13633 | biostudies-arrayexpress
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