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TranscriptomicsTranscription profiling of mouse Cftr knockout or wild type colonic epithelial cells treated with rosiglitazone
30-day-old Cftr-/- homozygous for the S489X, B6.129P2-Cftr(tm1Unc), mutation or sibling wild-type control mice were treated with standard chow or 20 mg/kg/d rosiglitazone for 5 days. Colonic epithelial cells were extracted and mRNA isolated. Cftr-/- mice suffer from a severe intestinal phenotype inc...
ORGANISM(S): Mus musculus 
2010-03-19 | E-MTAB-188 | biostudies-arrayexpress
UnknownMolecular Diversity of Hard Tick Species from Selected Areas of a Wildlife-Livestock Interface Ecosystem at Mikumi National Park, Morogoro Region, Tanzania.
Not available
S-EPMC7995979 | biostudies-literature
TranscriptomicsA mesodermal gene regulatory network directed by zebrafish No tail
Using chromatin immunoprecipitation combined with microarrays we have identified targets of No tail (Ntl), a zebrafish Brachyury ortholog that plays a central role in mesoderm formation. We show that Ntl regulates a downstream network of other transcription factors and identify an in vivo Ntl bindin...
ORGANISM(S): Danio rerio 
2009-02-19 | E-GEOD-12331 | biostudies-arrayexpress
GenomicsMutational patterns and regulatory networks in epigenetic subgroups of meningioma (H033)
DNA methylation patterns delineate clinically relevant subgroups of meningioma. We previously established the six meningioma methylation classes (MC) benign-1, 2, 3, intermediate-A, B and malignant. Here, we set out to identify subgroup-specific mutational patterns and pathway regulation. Whole-gen...
EGAS00001003481 | EGA
TranscriptomicsTestosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice
Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin (KISS1) do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these proteins in the hypothalamus have yet to be explored by genome-wide methods. Using micro-disse...
ORGANISM(S): Mus musculus 
2011-08-21 | E-GEOD-28383 | biostudies-arrayexpress
TranscriptomicsMouse Sirt6-/- RelA+/- tissues
We harvested spleen tissue from Sirt6-/- or Sirt6-/- RelA+/- animals and then completed genome-wide microarray analysis. Total RNA was extracted with TRIzol (Invitrogen) and amplified with Amino Allyl MessageAmp II Amplification kit. Amplified age-matched wild-type tissues were used as reference RNA...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-13209 | biostudies-arrayexpress
TranscriptomicsMouse Sirt6-/- tissues
We harvested liver, spleen, thymus, and skin tissues from 21 or 29 day old Sirt6-/- animals and then completed genome-wide microarray analysis. Total RNA was extracted with TRIzol (Invitrogen) and amplified with Amino Allyl MessageAmp II Amplification kit. Amplified age-matched wild-type tissues wer...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-13208 | biostudies-arrayexpress
GenomicsNational Cancer Institute Cancer Genome Characterization Initiative (CGCI)

The Office of Cancer Genomics at the National Cancer Institute is sponsoring a series of studies as part of the Cancer Genome Characterization Initiative (CGCI) to assess novel emerging sequencing technologies in cancer. The CGCI program includes comprehensive characterization of the genetic a...

phs000235.v3.p1 | EGA
GenomicsRole of Tet1 in genomic imprinting erasure [RRBS-PGC]
Genomic imprinting is an allele-specific gene expression system important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation 2. While it is well known that the de novo DNA methyltransferases Dnmt3a/b are responsible for the establishm...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-49762 | biostudies-arrayexpress
GenomicsRole of Tet1 in genomic imprinting erasure [RRBS-sperm]
Genomic imprinting is an allele-specific gene expression system important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation 2. While it is well known that the de novo DNA methyltransferases Dnmt3a/b are responsible for the establishm...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-49763 | biostudies-arrayexpress
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