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TranscriptomicsCell-cycle regulation of cohesin stability along fission yeast chromosomes
Sister chromatid cohesion is mediated by cohesin but the process of cohesion establishment during S phase is still enigmatic. Recent data indicate that in mammalian cells, cohesin binding to chromatin is dynamic in G1 but becomes stabilized during S phase. Whether the regulation of chromosomal cohes...
ORGANISM(S): Schizosaccharomyces pombe 
2007-11-30 | E-GEOD-8450 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat wild-type and (6) MRP2 deficient kidneys that had been transplanted in wild-type recipients reveals kidney-specific dysfunction of the organic anion transporter mrp2 (ABCC2): functional consequences for renal grafts
Transplanting renal allografts represents the major curative treatment of chronic renal failure. Despite recent advances in immunosuppressive therapy, long-term survival of allografts remains a major clinical problem. Kidney function depends in part on transport proteins such as MRP2 (ABCC2) which f...
ORGANISM(S): Rattus norvegicus 
2009-09-04 | E-GEOD-10949 | biostudies-arrayexpress
TranscriptomicsAnalysis of embryonic day E14.5 and E16.5 mouse ureters from Tshz3LacZ/LacZ mutants and wild types
In the urinary tract, smooth muscle (SM) is present in the renal pelvis, the ureter, the bladder and the urethra and plays a crucial role in the functional and structural integrity of these organs. In Tshz3 mutant ureters the myogenic program is not activated in the proximal region due to the absenc...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-43940 | biostudies-arrayexpress
TranscriptomicsDeletion of DMD exon 52 in the pig results in fulminant muscular dystrophy
Duchenne muscular dystrophy (DMD) is caused by mutations in the X-linked dystrophin (DMD) gene. The absence of dystrophin protein leads to progressive muscle weakness and wasting, disability and death. To establish a tailored large animal model of DMD, we deleted DMD exon 52 in male pig cells by gen...
ORGANISM(S): Sus scrofa 
2013-08-06 | E-GEOD-44096 | biostudies-arrayexpress
MetabolomicsThe suberin transporter StABCG1 is required for barrier formation in potato leaves

Suberin is a hydrophobic biopolymer that acts as an internal and external diffusion and transpiration barrier in plants. It is involved in two phases of wound healing, i.e. initial closing layer formation and subsequent wound periderm development. Transcriptomic and metabolomic analyses of wounde...

2024-09-19 | MTBLS4823 | MetaboLights
TranscriptomicsRibosome Profiling of mouse skin squamous tumours
Purpose: Ribosome profiling has revolutionized systems-based analysis and which produces a “global snapshot” of all the ribosomes translationally active in a cell at a particular moment. The goals of this study are to first apply ribosome profiling to in vivo samples for the first time and in pa...
ORGANISM(S): Mus musculus 
2016-06-16 | E-GEOD-72066 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type and Hfe-/- mice with hereditary hemochromatosis subjected to dietary iron overload and treatment with nifedipine to reverse iron overload
Hereditary hemochromatosis and transfusional iron overload are frequent clinical conditions associated with progressive iron accumulation in parenchymal tissues leading to eventual organ failure. We have discovered a novel mechanism to reverse iron overload by pharmacological modulation of the dival...
ORGANISM(S): Mus musculus 
2007-03-01 | E-MEXP-982 | biostudies-arrayexpress
TranscriptomicsFunctional analysis of the cytoprotective transcription factor Nrf2 in skin morphogenesis and disease: Identification of Nrf2 target genes
The Nrf2 transcription factor is a key player in the cellular stress response, which regulates the expression of important antioxidant enzymes and other cytoprotective proteins. We recently generated a novel transgenic mouse model to determine the function of Nrf2 in the skin. These mice revealed in...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-35160 | biostudies-arrayexpress
UnknownSpermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice.
Not available
S-EPMC2670665 | biostudies-literature
ProteomicsGlycosyltransferase POMGnT1 deficiency affects N-cadherin-mediated cell-cell adhesion
Deficiencies in the protein O-mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGNT1), a glycosyltransferase involved in the elongation of classic O-mannosyl glycans, are mainly associated with muscle-eye-brain disease (MEB), a genetically heterogeneous congenital muscular dystrophy with brain and ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD021321 | Pride
Pomgnt1 Pmgt1 Protein o-linked-mannose beta-1 2-n-acetylglucosaminyltransferase 1 Meb Pomgnt1 Mannosylation Muscular dystrophy-dystroglycanopathy Muscle-eye-brain disease Pomgnt1 
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