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ProteomicsDiversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain
Amyloid-beta (Aβ) plays a key role in the pathogenesis of Alzheimer’s disease (AD), but little is known about the proteoforms present in human AD brain. We used high-resolution mass spectrometry to analyze intact, undigested Aβ from purified soluble aggregates and insoluble material in brains of 6 c...
ORGANISM(S): Homo sapiens (Human) 
2017-08-28 | PXD006552 | Pride
Post-translational modifications (ptms) Amyloid-beta Proteoforms Alzheimer’s disease Top-down mass spectrometry Truncations 
ProteomicsRat Brain LC-MS/MS - Quantitative Proteomics Reveals Protein-Protein Interactions with Fibroblast Growth Factor12 as a Component of the Nav1
Voltage-gated sodium channels are responsible for the initiation and propagation of action potentials in excitable cells. While the channel is functional on its own, it is the transient and stable protein-protein interactions that modulate functional outcomes. AP-MS has been successfully applied to ...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-03-03 | PXD000719 | Pride
Ap-ms Mammalian brain Interactome 
ProteomicsExtraordinary Diversity of Amyloid-beta Proteoforms in Human Alzheimer's Disease Brain
Amyloid-beta (Aβ) plays a key role in the neuropathogenesis of Alzheimer’s disease, but little is known about the proteoforms (i.e., all protein variants of a single gene including post-translational modifications and sequence variants) present in human AD brain. We used high-resolution mass spectro...
ORGANISM(S): Homo sapiens (Human) 
2017-09-04 | PXD005119 | Pride
Human ad brain  nlc-ms/ms 
ProteomicsQuantitative Proteomics Reveals Metabolic Differences in Homing and Non-Homing Glioma Stem Cell Xenografts and Stromal Cells
Glioblastoma is the most common and most devastating adult primary brain tumor. Despite aggressive multimodal therapy, the median survival is approximately one year after diagnosis. In recent years bone marrow-derived human mesenchymal stem cells (BM-hMSCs) have shown promise as cell-based delivery ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Homo sapiens/Mus musculus xenograft 
2016-02-17 | PXD001778 | Pride
Fatty acid metabolism glycolysis Glycosylation Pentose phosphate pathway Mass spectrometry Cancer proteomics Glioblastoma Bone marrow-derived human mesenchymal stem cells (bm-hmscs) Transcriptomics 
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