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TranscriptomicsFOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development
The Forkhead Box, FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown herein, granulosa cel...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67662 | biostudies-arrayexpress
TranscriptomicsMammalian fetal ovary development
Ovarian follicular granulosa cells surround and nurture oocytes, and produce sex steroid hormones. It is believed that during development the ovarian surface epithelial cells invaginate into the ovary and develop into granulosa cells when associating with oogonia to form follicles. Using bovine fe...
ORGANISM(S): Bos taurus 
2014-05-20 | E-GEOD-42838 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse ovary development to compare the expression of mRNAs and noncoding RNAs
This experiment compared the expression of mRNAs and noncoding RNAs during the development of mouse ovary. The primary aim of the experiment was to identify ncRNAs that were differentially expressed during this process.
ORGANISM(S): Mus musculus 
2010-05-12 | E-TABM-986 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse testis development to compare the expression of mRNAs and noncoding RNAs
This experiment compared the expression of mRNAs and noncoding RNAs during the development of mouse testis. The primary aim of the experiment was to identify ncRNAs that were differentially expressed during this process.
ORGANISM(S): Mus musculus 
2010-05-12 | E-TABM-985 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulation of sex determination by the histone demethylase Jmjd1a
Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status including histone modification. Although several known transcription factors play crucial roles in mammalian sex determination, how chromatin regulation contributes to t...
ORGANISM(S): Mus musculus 
2013-08-03 | E-GEOD-49513 | biostudies-arrayexpress
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