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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
MetabolomicsElevated CO2 and virus infection impacts wheat and aphid metabolism

INTRODUCTION: The aphid Rhopalosiphum padi L. is a vector of Barley yellow dwarf virus (BYDV) in wheat and other economically important cereal crops. Increased atmospheric CO2 has been shown to alter plant growth and metabolism, enhancing BYDV disease in wheat. However, the bioch...

2019-01-16 | MTBLS622 | MetaboLights
TranscriptomicsMyeloid Dendritic Cells Induce HIV-1 Latency in Non-Proliferating CD4+ T Cells
Latently infected resting CD4+ T cells are a major barrier to HIV cure. Understanding how latency is established, maintained and reversed is critical to identifying novel strategies to eliminate latently infected cells. We demonstrate here that co-culture of resting CD4+ T cells and syngeneic myeloi...
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-52344 | biostudies-arrayexpress
TranscriptomicsExpression data from cord blood derived CD4+ CD25+ (Treg) and CD4+ CD25- (Thelper) cells, both while resting & after stimulation
Here we compare the effects of stimulation on cord blood derived CD4+ CD25+ (Treg) and CD4+ CD25- (Thelper) cells, isolated by MACS protocols & expanded in vitro using dynabeads. Expansion was carried out at a ratio of 3 beads/cell in the presence of 1000units/ml of recombinant human IL2 for 8 days,...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-20934 | biostudies-arrayexpress
UnknownEfficacy of tofacitinib monotherapy in methotrexate-naive patients with early or established rheumatoid arthritis.
Not available
S-EPMC4964179 | biostudies-literature
ProteomicsCo-translational and Post-translational protein myristoylation in HeLa cells
Protein N-myristoylation is a ubiquitous co- and post-translational modification that has been implicated in the development and progression of a range of human diseases. In E. Thinon, R. A. Serwa, et al., Nature Communications 2014, doi:10.1038/ncomms5919, we report the global N-myristoylated prote...
ORGANISM(S): Homo sapiens (Human) 
2018-07-31 | PXD002687 | Pride
Co-translational modification Post-translational modification Apoptosis Protein myristoylation 
UnknownFine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows.
Not available
S-EPMC5483290 | biostudies-literature
UnknownRelationship between clinical and patient-reported outcomes in a phase 3 trial of tofacitinib or MTX in MTX-naive patients with rheumatoid arthritis.
Not available
S-EPMC4860866 | biostudies-literature
UnknownEfficacy and safety of tofacitinib in patients with active rheumatoid arthritis: review of key Phase 2 studies.
Not available
S-EPMC5396326 | biostudies-literature
UnknownActivity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.
Not available
S-EPMC7831362 | biostudies-literature
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