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TranscriptomicsInhibitors that block initiation of wall teichoic acid biosynthesis sensitize methicillin-resistant Staphylococcus aureus to beta-lactams
Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase with reduced susceptibility to beta-lactam antibiotics. Here, we show that preventing the expression of wall teichoic acids...
ORGANISM(S): Staphylococcus aureus 
2010-10-19 | E-GEOD-24439 | biostudies-arrayexpress
TranscriptomicsGenes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers
Aflatoxins are carcinogenic fungal secondary metabolites. Levels of aflatoxins in agricultural commodities are stringently regulated by many countries. A cluster of genes is responsible for aflatoxin biosynthesis by Aspergillus flavus and other closely related species. Expression of the clustered af...
ORGANISM(S): Aspergillus flavus 
2010-05-26 | E-GEOD-8185 | biostudies-arrayexpress
TranscriptomicsLytic Effect of Terpeneless Cold Pressed Valencia Orange Oil on Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus has been recognized as an important cause of human disease for more than 100 years. Resistance to multiple classes of antibiotics is becoming an increasingly difficult problem in the management of methicillin-resistant S. aureus (MRSA) and vancomycin-intermediate resistant S. ...
ORGANISM(S): Staphylococcus aureus 
2011-11-08 | E-GEOD-33465 | biostudies-arrayexpress
ProteomicsA BRET Biosensor for Measuring Uncompetitive Engagement of PRMT5 Complexes in Cells
Protein arginine methyl transferase 5 (PRMT5) plays a global role in cell physiology and is an established therapeutic target in cancer. In approximately 10-15% of human cancers, deletion of the methylthioadenosine phosphorylase (MTAP) gene results in accumulation of methylthioadenosine (MTA), expos...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD028138 | Pride
Nanobret - chemical proteomics – cell-based assay – sam – target engagement – thermal profiling 
TranscriptomicsMicroarray analysis of stalk-eyed fly lines selected for divergent eyespan
Eye-stalks of some flies exhibit extreme sexual dimorphism, but little is known about the genetic mechanisms producing variation in these ornamental traits. Therefore, we constructed an EST database of genes expressed in the developing eye-antennal imaginal disc of the highly dimorphic species, Tele...
ORGANISM(S): Teleopsis dalmanni 
2010-06-24 | E-GEOD-15444 | biostudies-arrayexpress
TranscriptomicsAlterations in the transcriptome and antibiotic susceptibility of Staphylococcus aureus grown in the presence of diclofenac
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) which has been shown to increase the susceptibility of various bacteria to antimicrobials and demonstrated to have broad antimicrobial activity. This study describes transcriptome alterations in S. aureus strain COL grown with diclofenac ...
ORGANISM(S): Staphylococcus aureus subsp. aureus COL 
2011-07-18 | E-GEOD-30724 | biostudies-arrayexpress
TranscriptomicsAn antibiotic that inhibits a late step in wall teichoic acid biosynthesis induces the cell wall stress stimulon in Staphylococcus aureus
Wall teichoic acids (WTAs) are phosphate-rich, sugar-based polymers attached to the cell walls of most Gram-positive bacteria. In Staphylococcus aureus, these anionic polymers regulate cell division, protect cells from osmotic stress, mediate host colonization, and mask enzymatically susceptible pep...
ORGANISM(S): Staphylococcus aureus 
2012-01-12 | E-GEOD-34441 | biostudies-arrayexpress
UnknownA BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.
Not available
S-EPMC12675575 | biostudies-literature
UnknownAn engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.
Not available
S-EPMC7049955 | biostudies-literature
UnknownCharacterization of SETD3 methyltransferase-mediated protein methionine methylation.
Not available
S-EPMC7415985 | biostudies-literature
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