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TranscriptomicsComparison of hepatic gene expression in response to fasting or 2 week high fat diet
The metabolic syndrome represents a cluster of well-documented risk factors for the development of type 2 diabetes and cardiovascular disease. Next to visceral obesity, dyslipidemia and insulin resistance, excessive triglyceride accumulation in the liver has been implicated to play a role in the dev...
ORGANISM(S): Mus musculus 
2011-04-02 | E-GEOD-8576 | biostudies-arrayexpress
TranscriptomicsExpression data from primary human skin fibroblasts treated with vehicle (DMSO) and the antioxidant Trolox (0.5 mM, 96 hrs)
Three (3) independent cell cultures for each condition (DMSO and Trolox) were analyzed. The effect of Trolox was checked on the protein level (being an increased protein level of fully assembled mitochondrial complex I) using blue-native PAGE analysis (as described in Koopman et al., Biochim. Biophy...
ORGANISM(S): Homo sapiens 
2012-07-14 | E-GEOD-32502 | biostudies-arrayexpress
UnknownLong COVID symptoms in exposed and infected children, adolescents and their parents one year after SARS-CoV-2 infection: A prospective observational cohort study.
Not available
S-EPMC9495281 | biostudies-literature
Genomicsena-DATASET-LUMC-SASC-20-06-2016-14:39:18:482-20 - samples
Here we have from 64 samples, their corresponding fastq and bam files. The study group consisted of 17 obese women with normal glucose tolerance and 15 obese women with T2DM classified according to WHO standards. The groups were matched for age, BMI and waist circumference. All the women had been m...
EGAD00001002202 | EGA
GenomicsRNA sequencing data from visceral and abdominal subcutaneous adipose tissue from morbidly obese women with normal glucose tolerance or type 2 diabetes
The study group consisted of 17 obese women with normal glucose tolerance and 15 obese women with T2DM. Adipose tissue specimens were taken from the epigastric region of the abdominal wall (SAT) and from the major omentum (VAT). RNA was isolated and RNA sequencing was used to analyse the transcripto...
EGAS00001001872 | EGA
GenomicsLeiden University Medical Center Adipose tissue RNA-seq
Data Access Committee EGAC00001000503
EGAC00001000503 | EGA
ProteomicsRaw LFQ-MS data, profiling of hFWE4-positive vesicles and hFWE4-mediated alterations to cell surface proteome in epidermal keratinocytes
LFQ-MS profiling of hFWE4-positive vesicles and hFWE4-mediated alterations to cell surface proteome in epidermal keratinocytes
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-17 | MSV000095056 | MassIVE
TranscriptomicsOXPHOS complex I deficiency leads to transcriptional changes of the Nrf2-Keap1 pathway and selenoproteins.
Defective complex I (CI) is the most common type of oxidative phosphorylation (OXPHOS) disease in patients, with an incidence of 1 in 5,000 live births. Complex I deficiency can present in infancy or early adulthood and shows a wide variety of clinical manifestations, including Leigh syndrome, (card...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-27041 | biostudies-arrayexpress
TranscriptomicsExpression data from POLG1 patients and control subjects muscle
Pathogenic mutations in the catalytic DNA polymerase gamma (POLG1) gene result in the accumulation of mtDNA mutations, deletions and/or decrease of mtDNA copy number. These features interfere with proper functioning of the electron transport chain, mostly affecting metabolically active tissues such ...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-18715 | biostudies-arrayexpress
UnknownLow-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Not available
S-EPMC4311266 | biostudies-literature
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