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TranscriptomicsTranscription profiling validation of an custom mouse oligo array using liver samples following treatment with the hepatotoxin phenobarbital and variable hybridization protocols
The use of custom-made focused microarrays has become a popular alternative, allowing the study of genes relevant to a specific hypothesis. To address the limitations of commercial arrays in toxicogenomics investigations, we have developed a custom mouse oligonucleotide microarray, the HC ToxArrayTM...
ORGANISM(S): Mus musculus 
2006-10-30 | E-MEXP-525 | biostudies-arrayexpress
TranscriptomicsHigh throughput analysis of three human adipose cell lines PAZ6, SGBS and SW872
We report molecular characterization of human brown and white adipocytes. We showed that PAZ6 and SW872 cells exhibit classical molecular and phenotypic markers of brown and white adipocytes, respectively. However, SGBS cells presented a versatile phenotype of adipocyte Sequencing of three human adi...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-63190 | biostudies-arrayexpress
TranscriptomicsEffects of pulp and paper mill effluents on gene expression in the fathead minnow hypothalamus
We evaluated the possible mechanisms by which exposures to pulp and paper mill effluents gene expression in the fathead minnow hypothalamus Keywords: Toxicology Sexually mature fathead minnows were exposed to 100% pulp and paper mill effluents for 5 days. Tanks contained 4 females and 2 males. A ...
ORGANISM(S): Pimephales promelas 
2010-07-07 | E-GEOD-17130 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphoblastic and myeloblastic leukemia samples with and without MLL rearrangements specific and lineage specific signatures
Gene expression analysis identified a MLL translocation-specific signature of differentially expressed genes discriminating ALL and AML with and without MLL rearrangements. Gene expression signatures of acute lymphoblastic and myeloblastic leukemia samples with and without MLL rearrangements were an...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-14062 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of Candida clinical isolates of different species and infection sources

Candida species are the most common cause of opportunistic fungal infections. Rapid identification and novel approaches for the characterization of these fungi are of great interest to improve the diagnosis and the knowledge about their pathogenic properties. This study aimed to characte...

2024-07-09 | MTBLS1978 | MetaboLights
TranscriptomicsTranscription profiling of human dendritic cells treated with lipopolysaccharides and R848
Toll-like receptor (TLR) signalling activation by pathogens is critical to the induction of immune responses, and demands tight regulation. Chemokine ligand 2 (CCL2) secretion triggered by TLR4 or TLR8 engagement is strongly inhibited upon simultaneous activation of both TLRs in human monocyte-deriv...
ORGANISM(S): Homo sapiens 
2009-05-22 | E-MEXP-2183 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of leukemia samples prepared using different RNA isolation procedures
Microarray gene expression (MAGE) signatures allow insights into the transcriptional processes of leukemias and may evolve as a molecular diagnostic test. Introduction of MAGE into clinical practice of leukemia diagnosis will require comprehensive assessment of variation due to the methodologies. Fo...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-7757 | biostudies-arrayexpress
TranscriptomicsThe effect of bisphenol A on human preadipocyte differentiation.
Background: Exposure to the endocrine-disrupting chemical bisphenol A (BPA) is correlated with obesity and promotes adipogenesis of human preadipocytes into mature adipocytes. However, the mechanism of action of BPA-induced human adipogenesis in vitro remains to be fully characterized. Methods: In t...
ORGANISM(S): Homo sapiens 
2014-04-15 | E-GEOD-56085 | biostudies-arrayexpress
TranscriptomicsLamin A/C Is Required For ChAT-Dependent Neuroblastoma Differentiation: a microarray gene expression study
The mouse neuroblastoma N18TG2 clone is unable to differentiate and defective for the enzymes of the biosynthesis of neurotransmitters. The forced expression of choline acetyltransferase (ChAT) in these cells results in the synthesis and release of acetylcholine (Ach) and hence in the expression of ...
ORGANISM(S): Mus musculus 
2017-04-18 | E-GEOD-73591 | biostudies-arrayexpress
TranscriptomicsLack of hepatic response of microRNA in mice following DB[a,h]A exposure (Agilent miRNA)
Dibenzo[a,h]anthracene DB[a,h]A is a polycyclic aromatic hydrocarbon potent carcinogen. Few studies have investigated the role of DB[a,h]A on mRNA and miRNA expression. In this study a 10-week old male MutaTM Mouse were exposed to 6.25, 12.5, and 25 mg/kg/day DB[a,h]A by oral gavage for 28 cons...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-35195 | biostudies-arrayexpress
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