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TranscriptomicsThe hibernating phenotype assessed through transcript screening
Mammalian hibernation is a dramatic physiological transition that involves the controlled reduction of regulated body temperature and the consequent depression of all physiological processes. The resulting reduction of metabolism and associated energy expenditure permits survival during extended pe...
ORGANISM(S): Spermophilus lateralis 
2010-06-05 | E-GEOD-2033 | biostudies-arrayexpress
TranscriptomicsThe role of microRNAs in hepatic thyroid hormone signalling
MicroRNAs (miRNAs) are extensively in diverse biological processes. However, very little is known about the role of miRNAs in mediating thyroid hormones (TH) action. Maintenance of appropriate TH levels is known to be critically important for development, differentiation and maintenance of metabolic...
ORGANISM(S): Mus musculus 
2010-08-20 | E-GEOD-21277 | biostudies-arrayexpress
TranscriptomicsLack of hepatic response of microRNA in mice following chronic benzo(a)pyrene exposure (gene expression)
Benzo[a]pyrene (BaP) is a very extensively studied prototypical polycyclic aromatic hydrocarbons (PAHs). Previous work in our laboratory showed no changes of microRNA (miRNA) expression in liver following a 3 days exposure to BaP, suggesting a lack of miRNA transcriptional responses to aryl hydrocar...
ORGANISM(S): Mus musculus 
2011-10-18 | E-GEOD-24907 | biostudies-arrayexpress
TranscriptomicsHepatic miRNA profiles and thyroid hormone homeostasis in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS) [mRNA]
Perfluorooctanesulfonate (PFOS) has been widely used in a variety of industrial and commercial applications as a surfactant and stain repellent. PFOS causes liver damage (including liver tumors) in experimental animals, primarily via interaction with PPARa and CAR/PXR. We investigated the involvemen...
ORGANISM(S): Rattus norvegicus 
2015-08-01 | E-GEOD-69520 | biostudies-arrayexpress
TranscriptomicsRetinoid X receptor gamma signaling accelerates CNS remyelination
The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. Here we generate a comprehensive transcriptional profile of the separate stages of spontaneous remyelination following focal demyelination in the rat CNS. White matter tracts in the rat caudal cerebellar peduncles...
ORGANISM(S): Rattus norvegicus 
2010-10-22 | E-GEOD-24821 | biostudies-arrayexpress
UnknownPreliminary model assessing the cost-effectiveness of preoperative chlorhexidine mouthwash at reducing postoperative pneumonia among abdominal surgery patients in South Africa.
Not available
S-EPMC8360544 | biostudies-literature
GenomicsGoT2D: Genetics of Type 2 Diabetes, a study of the the genetic architecture of type 2 diabetes using low pass whole genome sequencing and high density SNP genotyping in 2,657 individuals.
The Genetics of Type 2 Diabetes Consortium (GoT2D) is a collaboration between the University of Michigan, the Broad Institute and the Wellcome Trust Centre for Human Genetics. The overall aim is to extend upon recent efforts, such as genome-wide association studies (GWAS) and large scale meta-analys...
EGAS00001001459 | EGA
Genomicsena-DATASET-GoT2D/T2D-GENES-09-07-2016-02:03:47:226-1135 - samples
The GoT2D study includes ~2800 samples, half T2D cases and half T2D controls, of Northern European ancestry sequenced over 3 three technologies: deep whole exome sequencing, low-pass (4x) whole genome sequencing, and OMNI 2.5M genotyping. Samples were ascertained to be phenotypically "extreme" (e.g....
EGAD00001002247 | EGA
UnknownThe antigenic anatomy of SARS-CoV-2 receptor binding domain.
Not available
S-EPMC7891125 | biostudies-literature
MetabolomicsGNPS - GNPS Paper Novel Stenothricin Analog Supporting Information.
Mass spectrometry data, NMR, and sequencing data in support of the discovery of stenothricin-GNPS. Secondary metabolite production of Streptomyces Roseosporus was compared against Streptomyces DSM5940.
ORGANISM(S): Streptomyces (ncbitaxon:1883) 
2015-07-30 | MSV000079204 | GNPS
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