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MetabolomicsAggressive breast cancers secrete heme metabolites to alter macrophage immune suppression and function
The heme catabolism pathway is often elevated in aggressive cancers; however, the impact of this pathway and some of its byproducts on the tumor microenvironment remain largely unknown. In human breast cancers, tumor expression of the heme catabolizing enzyme heme oxygenase-1 (HO-1/HMOX1) is positiv...
2026-04-24 | MTBLS14278 | MetaboLights
MetabolomicsAtlas of one-carbon metabolism in conventional and germ-free mice reveals folate as a key determinant of biochemical pathways

Folates participate in the one-carbon metabolism (OCM) cycle, supporting many biochemical pathways. Existing methods to profile folate are limited in the diversity of vitamers they measure and the samples they profile. We present a metabolomics workflow for stable extraction, separation, and meas...

2026-02-10 | MTBLS13484 | MetaboLights
TranscriptomicsTranscription profiling of wild type and dbr1-delta strains of Candida albicans grown under standard or various mixed conditions
Probes flanking all predicted Candida albicans ORFs are used to detect intron sequences that accumulate in a debranchase (DBR1) mutant. We synthesized cDNA from RNA from both wild-type and dbr1-delta mutant strains grown under standard (YEPD) or various mixed conditions, labeled the two populations...
ORGANISM(S): Candida albicans 
2007-02-22 | E-MEXP-1003 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of hMADS cells transfected with miR-26a
Human multipotent adipose-derived stem (hMADS) cells were transfected at confluence with miR-26a or miR-C (non-targeting control microRNA) and cells were harvested two days later (=d0) to identify mRNAs that are downregulated by miR-26a versus miR-C, as such mRNAs could be direct miR-26a targets.
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MARS-28 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of hMADS cells transfected with miR-26a and induced to differentiate into adipocytes
Human multipotent adipose-derived stem (hMADS) cells were transfected at confluence with miR-26a or miR-C (non-targeting control microRNA). Two days later (=d0), adipocyte differentiation was induced. At d9 after start of differentiation, cells were harvested to identify mRNAs that are down- and upr...
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MARS-29 | biostudies-arrayexpress
TranscriptomicsCoordination in the transcriptome and proteome of the diatom Thalassiosira pseudonana reveals a diverse phosphorus stress response
Phosphorus (P) is a critical driver of phytoplankton growth and ecosystem structure and function in the ocean. Diatoms are an abundant and widespread functional group of phytoplankton that are responsible for significant amounts of primary production in the ocean, however there has not been a compre...
ORGANISM(S): Thalassiosira pseudonana CCMP1335 
2013-08-03 | E-GEOD-28134 | biostudies-arrayexpress
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