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Hver2.1.1 microarrays containing ~15,000 genes were used to characterize the gene expression profiles of Vg9/Vd2 T cells upon 72h stimulation with HMB-PP in the presence of IL-2, IL-4, or IL-21.
ORGANISM(S): Homo sapiens 
Comparing Vg9Vd2 T cells with CD8 ab T cells
To compare the responses of resting and activated human Vg9Vd2 T cells (mainly CD4-CD8-) to those of conventional CD8+ ab T cells, we used Hver2.1.1 microarrays containing ~15,000 cDNAs. CD8 T cells were chosen as the conventional counterpart of huma...
ORGANISM(S): Homo sapiens 
One of the eminent opportunities afforded by modern genomic technologies is the potential to provide a mechanistic understanding of the processes by which genetic change translates to phenotypic variation and the resultant appearance of distinct physiological traits. Indeed much progress has been m...
ORGANISM(S): Arabidopsis thaliana 
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
Pancreatic β-cells have the key homeostatic function of releasing insulin to keep blood glucose in the normal range. It is not fully understood how β-cell mass is determined. Ablation of a nuclear receptor, chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), in mouse pancreat...
ORGANISM(S): Rattus norvegicus 
Validation of a custom low density microarray. Gene expression differences were analysed in the following groups of blood samples and cell lines:
Two haematological neoplasia cell lines: U937 (promonocytic lymphoma) versus Jurkat (T leukemia).
Different types of haematological neoplasias: heal...
ORGANISM(S): Homo sapiens 
To address the protective mechanisms generated in animals on previous exposure to this parasite, using samples of abomasal mucosa collected pre- and post- challenge from animals of differing immune status in an experimental model of T. circumcincta infection.
ORGANISM(S): Ovis aries 

Gut environments harbour dense microbial ecosystems in which plasmids are widely distributed. Plasmids facilitate the exchange of genetic material among microorganisms while enabling the transfer of a diverse array of accessory functions. However, their precise impact on microbial community compo...

2023-08-10 | MTBLS7248 | MetaboLights
Tumour expression profiling was performed on resected brain tumour tissue following its histological categorisation. Classification of tumour type was carried out according to WHO criteria by a panel of independent pathologists across the etumour consorteum. This gave a high quality diagnostic eva...
ORGANISM(S): Homo sapiens 
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