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TranscriptomicsChromatin immunoprecipitation of Oct4, Nanog and Suz12 in human and mouse embryonic stem cells to identify promoters for miRNAs
Understanding the transcriptional regulatory circuitry responsible for pluripotency and self-renewal in embryonic stem (ES) cells is fundamental to understanding human development and realizing the therapeutic potential of these cells. The transcription factor Oct4 and the chromatin-modifying Polyc...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-TABM-365 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation genome wide binding sites of Oct4, Sox2, and Nanog in human
The transcription factors Oct4, Sox2, and Nanog have essential roles in early development and are required for the propagation of undifferentiated embryonic stem (ES) cells in culture. To gain insights into transcriptional regulation of human ES cells, we have identified Oct4, Sox2, and Nanog target...
ORGANISM(S): Homo sapiens 
2005-09-23 | E-WMIT-5 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Tcf3, Oct4 and nanog in mouse embryonic stem cells
Embryonic stem cells have a unique regulatory circuitry, largely controlled by the transcription factors Oct4, Sox2 and Nanog, which generates a gene expression program necessary for pluripotency and self-renewal (Boyer et al. 2005; Loh et al. 2006; Chambers et al. 2003; Mitsui et al. 2003; Nichols ...
ORGANISM(S): Mus musculus 
2008-02-28 | E-TABM-409 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cells carrying an extra copy of human chromosome 21 and their wild type counterparts to model Down&aposs Syndrome
Comparison of mouse embryonic stem (ES) cells carrying an extra copy of human chromosome 21 (HSA21) with their WT counterparts. The transchromosomic cells are called 47-1, and the parental WT cells are called D3.
ORGANISM(S): Mus musculus 
2008-09-04 | E-MEXP-654 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse polycomb group (PcG) proteins in embryonic stem cells
Polycomb group (PcG) proteins are highly conserved from flies to mammals and many of these factors have essential roles in early embryonic development. PcG proteins comprise two multimeric complexes, the Polycomb Repressive complexes 1 and 2 (PRC1 and 2), which have been shown to repress transcript...
ORGANISM(S): Mus musculus 
2006-05-09 | E-WMIT-12 | biostudies-arrayexpress
TranscriptomicsHematopoietic differentiation of human embryonic stem cells - timecourse and d7 CD34 and CD41 fractions
This study aimed to examine gene expression in human ES cells (the RUNX1C GFP reporter line) differentiated towrads hameatopoietic mesoderm in a defined serum free medium. At day 7 of differentiation, the cells were sorted into fractions based on CD34 and CD41 expression and the four fractions analy...
ORGANISM(S): Homo sapiens 
2015-01-13 | E-GEOD-64876 | biostudies-arrayexpress
TranscriptomicsActivation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. doi: 10.1038/nm.4109
The multiple claims about reactivation of the embryonic stem cell (ESC) pluripotency factor OCT4 in somatic cells are highly controversial due to the fact that there is no direct evidence that OCT4 has a functional role in cells other than ESCs. Herein we demonstrate that smooth muscle cell (SMC)-sp...
ORGANISM(S): Mus musculus 
2016-05-15 | E-GEOD-75044 | biostudies-arrayexpress
UnknownRecurrent heterozygous PAX6 missense variants cause severe bilateral microphthalmia via predictable effects on DNA-protein interaction.
Not available
S-EPMC7056646 | biostudies-literature
UnknownElective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
Not available
S-EPMC8189635 | biostudies-literature
UnknownImpact of COVID-19 in patients on active melanoma therapy and with history of melanoma.
Not available
S-EPMC10033295 | biostudies-literature
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