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TranscriptomicsExpression profiling in Williams-Beuren Syndrome patient fibroblast cell lines
Williams-Beuren Syndrome (WBS) is a neurodevelopmental disorder caused by aa 1.5 Mb microdeletion on human chromosome 7. Although the molecular cause of the disorder is well-established, little is known about the global impact of the deletion on gene expression. Here we profiled the transcriptomes o...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-16715 | biostudies-arrayexpress
ProteomicsTime-course global proteome analyses in the APPNL-F mouse model of Alzheimer disease
A hallmark of Alzheimer Disease is the accumulation of aggregation-prone amyloid beta peptides, which can assemble into smaller aggregates and deposit in the form of amyloid plaques. Here we used the recently introduced APPNL-F mouse model of Alzheimer Disease, which faithfully recapitulates the amy...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-02 | PXD004439 | Pride
Mouse Brain Amyloid beta Lc-ms/ms 
ProteomicsPhosphorylation of Cyclin F at Serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(Cyclin F) complex.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and cachexia often resulting in patient death within 3-5 years of diagnosis. Recently, we identified mutations to the CCNF gene, which encodes the Cyclin F protein, in c...
ORGANISM(S): Homo sapiens (Human) 
2017-12-08 | PXD004531 | Pride
Als Phosphorylation Ubiquitylation E3 ligase 
ProteomicsCharacterisation of the gut microbiota metaproteome in patients affected by the Williams Beuren syndrome
Analyses were performed on stool samples collected from 41 patients affected by Williams Beuren syndrome (Wills, WBSs) to evaluate their gut microbiota metaproteome signatures by LFQ and LCA approaches in comparison to 45 healthy subjects (controls, CTRs, CTRLs)
ORGANISM(S): Bacteria (ncbitaxon:2) Homo Sapiens (ncbitaxon:9606) 
2023-01-11 | MSV000091045 | MassIVE
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli
This SuperSeries is composed of the following subset Series: GSE39928: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [35MM] GSE39929: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [40MM] GSE39930: Murine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [41MM] GSE39931: Muri...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39932 | biostudies-arrayexpress
TranscriptomicsComparative Transcriptomics of Soybean Near Isogenic Lines in Response to Phytophthora Sojae
Phytophthora root and stem rot (PRR) of soybean, caused by Phytophthora sojae, is effectively controlled by Rps genes in soybean. Rps genes are race-specific, yet the mechanism of resistance, as well as susceptibility, remains largely unclear. Taking advantage of RNA-seq technology, we sequenced the...
ORGANISM(S): Glycine max 
2014-04-16 | E-GEOD-48524 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [35MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39928 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [41MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39930 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [40MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39929 | biostudies-arrayexpress
TranscriptomicsMurine livers post DEN treatment: c-Jun f/f vs. c-Jun Dli [43MM]
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week in mouse livers as measured by Western blots and immunohistochemical staining. DEN-induced liver tum...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-39931 | biostudies-arrayexpress
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