Sort   by:  
 Page size 
UnknownThe Trp-cage: optimizing the stability of a globular miniprotein.
Not available
S-EPMC3166533 | biostudies-literature
TranscriptomicsKras mutant v WT with or without AZD6244 in vivo study
HCT116 (kRas mt) cells and HKH2 (Kras wt) cells were implanted into the right and left flanks of nude mice and either untreated or treated with a MEK inhibitor (AZD6244) over time. Tumours were excised and harvested for RNA extraction at the end of the experiment and hybridised to the Colorectal DS...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-MEXP-3557 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary fibroblasts from a family with autosomal recessive Hutchinson-Gilford Progeria Syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder displaying features reminiscent of premature senescence caused by germline mutations in the LMNA gene encoding lamin A and C, essential components of the nuclear lamina. By studying a family with homozygous LMNA mutation (K542N), we s...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-MEXP-3097 | biostudies-arrayexpress
UnknownWhole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.
Not available
S-EPMC12418676 | biostudies-literature
TranscriptomicsTargeting resistance to Smoothened antagonists by inhibiting the PI3K pathway
Mutations in Hedgehog (Hh) pathway genes, leading to constitutive activation of Smoothened (Smo), occur in sporadic medulloblastoma, the most common brain cancer in children. Antagonists of Smo induce tumor regression in mouse models of medulloblastoma and hold great promise for targeted therapy fo...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-19657 | biostudies-arrayexpress
UnknownDominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome.
Not available
S-EPMC4706118 | biostudies-literature
MetabolomicsThe Bardet-Biedl protein Bbs1 controls photoreceptor outer segment protein and lipid composition

Summary

Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies, since the outer segments (OSs) of photoreceptors are highly specialized primary cilia. BBS...

2022-02-18 | MTBLS4013 | MetaboLights
UnknownPrediction of Fluoroquinolone Susceptibility Directly from Whole-Genome Sequence Data by Using Liquid Chromatography-Tandem Mass Spectrometry To Identify Mutant Genotypes.
Not available
S-EPMC5826109 | biostudies-literature
UnknownDiet quality of adolescents in rural Sri Lanka based on the Diet Quality Index-International: findings from the 'Integrating Nutrition Promotion and Rural Development' project.
Not available
S-EPMC10260602 | biostudies-literature
MetabolomicsUncovering the Complexity of the Yeast Lipidome by Means of nLC/NSI-MS/MS
Saccharomyces cerevisiae is a eukaryotic model organism widely used for the investigation of fundamental cellular processes and disease mechanisms. Consequently, the lipid landscape of yeast has been extensively investigated and up to this day the lipidome is considered as rather basic. Here, we use...
2021-01-08 | MTBLS2119 | MetaboLights
Sort   by:  
 Page size