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TranscriptomicsTranscription profiling by array of paired tumour and normal samples from colorectal cancer patients undergoing colonic resection to investigate quality assessment and data handling methods for Affymetrix Gene 1.0 ST arrays with variable RNA integrity
We investigate the relevance of RNA integrity in gene expression analysis as well as analysis methods to accommodate the possible effects of degradation using paired tumour and normal samples from colorectal cancer patients undergoing colonic resection.
ORGANISM(S): Homo sapiens 
2012-10-31 | E-MEXP-3715 | biostudies-arrayexpress
TranscriptomicsB-type lamins differentially associate with specific genes during differentiation without directly affecting their expression
B-type lamins, the major structural component of the nuclear lamina, is thought to play a repressive role in the expression of many of its bound genes whose silencing are known to be critical for cell differentiation during early development. Using global mapping of lamin-B-chromatin interaction, w...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-24532 | biostudies-arrayexpress
GenomicsSystematic identification of G-quadruplex sensitive lethality by genome-wide genetic screening
A375 and HT1080 cells are treated with G-quadruplex ligands PDS or PhenDC3 following genome-wide shRNA knockdown. This enables the identification of genes that when silenced, specifically compromises cell growth in the presence of the ligand. First, a pilot screen was performed to determine a ligand...
ORGANISM(S): Homo sapiens 
2019-06-22 | E-MTAB-6367 | biostudies-arrayexpress
UnknownSMIM1 absence is associated with reduced energy expenditure and excess weight.
Not available
S-EPMC7617389 | biostudies-literature
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