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TranscriptomicsEffect of p38 MAPK inhibitor SB203580 on gene expression in monocytic THP-1 cells stimulated with HIV gp120 or LPS.
Human monocytic THP-1 cells were exposed to HIV envelope protein gp120 or bacterial LPS in the presence and absence of a pharmacological inhibitor of the p38 mitogen-activated protein kinase (MAPK) for 4 and 24 hours. A microarray analysis was performed in order to assess differential gene expressio...
ORGANISM(S): Homo sapiens 
2014-12-25 | E-GEOD-53712 | biostudies-arrayexpress
UnknownInduced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.
Not available
S-EPMC3378107 | biostudies-literature
TranscriptomicsTranscription profiling of ischemia-reperfused Rattus norvegicus heart tissue samples
Rats underwent surgery for LAD ligation for 30 min followed by reperfusion. Heart ventricles were collected 2d or 7d after reperfusion. Experiment Overall Design: rats were divided in following groups that underwent LAD occlusion or not (SHAM): Experiment Overall Design: 1. 7d-IR (n=3) Experiment O...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-4105 | biostudies-arrayexpress
TranscriptomicsS100A8/A9 activate key genes and pathways in colon tumor progression
Studies using bone marrow chimeric mice revealed that S100A8/A9 expression on myeloid cells is essential for development of colon tumors. Our results thus reveal a novel role for myeloid-derived S100A8/A9 in activating specific downstream genes associated with tumorigenesis and in promoting tumor gr...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-26359 | biostudies-arrayexpress
TranscriptomicsCCR5 controls neuronal damage in an in vivo model of HIV glycoprotein 120-induced brain injury
The chemokine receptor CCR5 is a major co-receptor for human immunodeficiency virus 1 (HIV-1) mediating infection of target cells1,2. Beyond its function as co-receptor, CCR5 also influences the course of HIV disease and progression to AIDS3. However, it is unclear how CCR5 affects HIV-associated da...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-47029 | biostudies-arrayexpress
TranscriptomicsAn Association Between Gene Expression and Better Survival in Female Mice Following Myocardial Infarction
Following myocardial infarction, the prognosis for females is better than males. Estrogen is thought to be protective, but clinical trials with hormone replacement failed to show protection. Here, we sought to identify novel mechanisms that might explain this sex-based difference. By diverging from ...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23294 | biostudies-arrayexpress
TranscriptomicsSignal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodeling complex
Tissue-specific transcription factors initiate differentiation toward a specialized cell type by inducing transcription-permissive chromatin modifications at target gene promoters, through the recruitment of the SWI/SNF chromatin-remodeling complex (1, 2). The molecular mechanism that regulates the ...
ORGANISM(S): Mus musculus 
2011-03-07 | E-GEOD-24573 | biostudies-arrayexpress
TranscriptomicsPhenothiazine Neuroleptics Signal To The Human Insulin Promoter As Revealed By A Novel Human b-Cell Line Based Screen
(original Title) Phenothiazine Neuroleptics Signal To The Human Insulin Promoter As Revealed By A Novel Human b-Cell Line Based High-Throughput Screen. To address the current deficiency in human beta-cell models, we have developed a cell line from human islets in which the expression of insulin and...
ORGANISM(S): Homo sapiens 
2010-08-06 | E-GEOD-18821 | biostudies-arrayexpress
TranscriptomicsRibosome profiling of Japanese encephalitis virus infected Neuro2a cells
Ribosome profiling (Ribo-Seq) and RNA-Seq analysis of mouse neuroblastoma (Neuro2a) cells infected with Japanese Encephalitis Virus (JEV) P20778 Vellore strain. At 18 h post infection (p.i.), infected cells were treated with either cycloheximide (translation elongation inhibitor) or in combination w...
ORGANISM(S): Mus musculus 
2021-07-05 | E-MTAB-9352 | biostudies-arrayexpress
UnknownDrosophila eggshell production: identification of new genes and coordination by Pxt.
Not available
S-EPMC3102670 | biostudies-literature
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