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TranscriptomicsThe cell envelope stress response mediated by the LiaFSRLm three-component system of Listeria monocytogenes is controlled via the phosphatase activity of the bifunctional histidine kinase LiaSLm
Most members of the phylum Firmicutes harbor a two-component system, LiaSR, which is involved in the response to cell envelope stress elicited most notably by inhibitors of the lipid II cycle. In all LiaSR systems studied in detail LiaSR-mediated signal transduction was shown to be negatively contro...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-11-16 | E-GEOD-24107 | biostudies-arrayexpress
TranscriptomicsNF-kB target genes in dendritic cells
The ability of dendritic cells (DC) to initiate immunity and induce antigen-specific tolerance makes DC ideal targets for pharmacological intervention into immune responses. NF-kB factors are a family of transcriptional regulators important for DC development and function. However, the identity of N...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-8009 | biostudies-arrayexpress
TranscriptomicsVitamin D3 affects TNFa mediated activation of dendritic cells
The ability of dendritic cells (DC) to initiate immunity and induce antigen-specific tolerance makes DC ideal targets for pharmacological intervention into immune responses. NF-kB factors are a family of transcriptional regulators important for DC development and function. However, the identity of N...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-8334 | biostudies-arrayexpress
ProteomicsA technique to identify context-based protein biomarkers: Application to a mouse liver cancer model
To date, most proteomic analyses towards cancer biomarker discovery have been based on protein quantification. However, proteins function in association with other proteins to form modules that are localized in specific subcellular compartments. Cellular mislocalization of proteins has in fact been...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD008758 | Pride
Cancer Mouse liver Swath-ms 
ProteomicsA new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model (validation part)
To-date, most proteomic studies aimed at discovering tissue-based cancer biomarkers have compared the quantity of selected proteins between case and control groups. However, proteins generally function in association with other proteins to form modules localized in particular subcellular compartment...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD013295 | Pride
Mouse Cancer Biomarker Liver 
ProteomicsDetection of Five Solid Carcinomas Using Blood Circulating Proteins
When diagnosed in a metastatic stage cancer is mostly incurable making its early detection via biomarkers of immense clinical interest. Proteins circulating in blood are a preferred source of biomarkers for a wide range of cancers due to the ease and non-invasiveness of collection. Our approach to c...
ORGANISM(S): Homo sapiens (Human) 
2018-08-09 | PXD004998 | Pride
N-glycoprotein Biomarker Swath-ms Plasma 
Genomicsena-DATASET-WIMM-10-10-2016-16:24:16:111-38 - samples
Whole Genome Sequencing data set for the study "Premalignant SOX2 in ovarian cancer patients"
EGAD00001002734 | EGA
GenomicsPremalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies
To identify early driver mutations in ovarian cancer cells, we used dense whole genome sequencing of micrometastases and microscopic residual disease collected at three time points from a single patient during treatment for high-grade serous ovarian cancer (HGSOC). Laser capture microdissection of t...
EGAS00001001909 | EGA
GenomicsOvarian Cancer Laboratory, University of Oxford
Data Access Committee EGAC00001000518
EGAC00001000518 | EGA
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