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ProteomicsPOGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of FBN1
Fibrillin-1 (FBN1) is the major component of extracellular matrix microfibrils, which are required for proper development of elastic tissues including heart and lung. Through protein-protein interactions with latent TGF-beta binding protein 1 (LTBP1), microfibrils assist regulation of TGF-beta signa...
ORGANISM(S): Homo sapiens (Human) 
2021-08-06 | PXD025725 | Pride
Extracellular matrix protein Egf repeats Mass spectrometry Glycosylation Protein secretion Protein folding 
ProteomicsPoglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues
Fibrillins, which are extensively O-glucosylated by POGLUT2 and 3, are crucial for development and cardiopulmonary function. Using primary dermal fibroblasts derived from our POGLUT 2 and 3 double knockout mouse model combined with proteomics analyses, we show that loss of O-glucose modifications on...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-10 | PXD043730 | Pride
Mouse Q exactive Dermal fibroblasts Secretome Extracellular matrix 
UnknownTherapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
Not available
S-EPMC8362592 | biostudies-literature
UnknownEfficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico.
Not available
S-EPMC8693692 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
Not available
S-EPMC8362594 | biostudies-literature
UnknownGlobal surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2).
Not available
S-EPMC4588097 | biostudies-literature
UnknownWorldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2).
Not available
S-EPMC6195190 | biostudies-literature
UnknownThe histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2).
Not available
S-EPMC6195192 | biostudies-literature
UnknownWorldwide comparison of survival from childhood leukaemia for 1995-2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries.
Not available
S-EPMC5418564 | biostudies-literature
UnknownA randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema.
Not available
S-EPMC2748264 | biostudies-literature
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