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ProteomicsLoss of POGLUT2 and 3 eliminates O-glucose at predicted sites but does not alter other modifications on EGFs
Fibrillins play a critical role in tissue/organ development and cardiopulmonary function. Here we showed that O-glucosylation of the fibrillins’ epidermal growth factor-like repeats by protein O-glucosyltransferase 2 (POGLUT2) and POGLUT3 was indispensable for in vivo function of mouse fibrillins. L...
ORGANISM(S): Mus Musculus 
PXD043827 | panorama
ProteomicsPoglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues
Fibrillins, which are extensively O-glucosylated by POGLUT2 and 3, are crucial for development and cardiopulmonary function. Using primary dermal fibroblasts derived from our POGLUT 2 and 3 double knockout mouse model combined with proteomics analyses, we show that loss of O-glucose modifications on...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-10 | PXD043730 | Pride
Mouse Q exactive Dermal fibroblasts Secretome Extracellular matrix 
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