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ProteomicsUnresolved stalled ribosome complexes restrict cycle progression after genotoxic stress
Translation of damaged mRNA can lead to ribosome stalling, thereby producing incomplete proteins toxic to the cell. The mechanism of ribosome-associated quality control (RQC) disassembles stalled ribosomes through the actions of the ASC-1 complex (ASCC). Here, we show that some reagents that chemica...
ORGANISM(S): Homo sapiens (Human) 
2022-02-07 | PXD023878 | Pride
Rna damage Rna interactome capture Ascc3 Asc-1 complex Ribosome-associated quality control 
ProteomicsUnresolved stalled ribosome complexes restrict cycle progression after genotoxic stress
Translation of damaged mRNA can lead to ribosome stalling, thereby producing incomplete proteins toxic to the cell. The mechanism of ribosome-associated quality control (RQC) disassembles stalled ribosomes through the actions of the ASC-1 complex (ASCC). Here, we show that some reagents that chemica...
ORGANISM(S): Homo sapiens (Human) 
2022-02-07 | PXD023976 | Pride
Rna damage Rna interactome capture Ascc3 Asc-1 complex Ribosome-associated quality control 
ProteomicsUnresolved stalled ribosome complexes restrict cycle progression after genotoxic stress
Translation of damaged mRNA can lead to ribosome stalling, thereby producing incomplete proteins toxic to the cell. The mechanism of ribosome-associated quality control (RQC) disassembles stalled ribosomes through the actions of the ASC-1 complex (ASCC). Here, we show that some reagents that chemica...
ORGANISM(S): Homo sapiens (Human) 
2022-02-07 | PXD023978 | Pride
Rna damage Rna interactome capture Ascc3 Asc-1 complex Ribosome-associated quality control 
ProteomicsUnresolved stalled ribosome complexes restrict cycle progression after genotoxic stress
Translation of damaged mRNA can lead to ribosome stalling, thereby producing incomplete proteins toxic to the cell. The mechanism of ribosome-associated quality control (RQC) disassembles stalled ribosomes through the actions of the ASC-1 complex (ASCC). Here, we show that some reagents that chemica...
ORGANISM(S): Homo sapiens (Human) 
2022-02-07 | PXD023861 | Pride
Rna damage Rna interactome capture Ascc3 Asc-1 complex Ribosome-associated quality control 
UnknownAcceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants.
Not available
S-EPMC3837047 | biostudies-literature
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