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GenomicsA master cistromic circuit governing hepatic fibrogenesis [ChIP-seq]
Liver fibrosis is a reversible wound-healing response to liver injury and hepatic stellate cells (HSCs) are central cellular players that mediate hepatic fibrogenesis. However, the molecular mechanisms that govern this process remain unclear. Here, we reveal a novel cistromic circuit in HSCs compris...
ORGANISM(S): Homo sapiens 
2013-04-29 | E-GEOD-38103 | biostudies-arrayexpress
TranscriptomicsA master cistromic circuit governing hepatic fibrogenesis [expression array]
Liver fibrosis is a reversible wound-healing response to liver injury and hepatic stellate cells (HSCs) are central cellular players that mediate hepatic fibrogenesis. However, the molecular mechanisms that govern this process remain unclear. Expression profiling was used to explore the potential im...
ORGANISM(S): Rattus norvegicus 
2013-04-29 | E-GEOD-41579 | biostudies-arrayexpress
TranscriptomicsA Master Cistromic Circuit Governing Hepatic Fibrogenesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2013-04-29 | E-GEOD-41580 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis microgametogenesis
Aims We aim to use transcriptome analysis to establish on a genome-wide scale the identity and regulatory clusters of genes that specify microgametogenesis from the haploid microspore to mature functional pollen in Arabidopsis. Background Pollen as the haploid male gametophyte plays a vital role in ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6162 | biostudies-arrayexpress
GenomicsThe androgen receptor induces a distinct transcriptional program in castration resistant prostate cancer in man
The androgen receptor (AR) is the major transcriptional driver of prostate cell growth in man. For the first time, we define AR targets in prostate cancer (PC) tissue representing progression from treatment-naive to castrate-resistant disease (CRPC). We employed chromatin immunoprecipitation with hi...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-28219 | biostudies-arrayexpress
MetabolomicsDelayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur in parallel; ...
2024-10-24 | MTBLS7919 | MetaboLights
TranscriptomicsDetermining single-cell mRNA expression profiles of a specific population isolated from zebrafish embryos at 10 hours post fertilization
Stable zebrafish cell lines were created that expressed GFP under the control of a previously characterized mouse Smarcd3 enhancer (10.7554/eLife.03848). Specifically, the 2.7 kb Mouse Smarcd3-F6 sequence (chr5: 24113559 -24116342 from mm9 assembly) was sub-cloned from a gateway entry vector into th...
ORGANISM(S): Danio rerio 
2018-08-20 | E-MTAB-6077 | biostudies-arrayexpress
UnknownCausal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.
Not available
S-EPMC3564800 | biostudies-literature
TranscriptomicsDetermining open chromatin profiles of a specific population of cells isolated from zebrafish embryos at 10 hours post fertilization using the ATAC-seq method
Stable zebrafish cell lines were created that expressed GFP under the control of a previously characterized mouse Smarcd3 enhancer (10.7554/eLife.03848). Specifically, the 2.7 kb Mouse Smarcd3-F6 sequence (chr5: 24113559 -24116342 from mm9 assembly) was sub-cloned from a gateway entry vector into th...
ORGANISM(S): Danio rerio 
2018-08-21 | E-MTAB-6078 | biostudies-arrayexpress
TranscriptomicsATAC-seq of gata5GFP+/- cells in WT and Gata5/6 deficient zebrafish embryos during gastrulation
Gata5/6 are essential regulators in zebrafish heart development. To understand how Gata5/6 affects the chromatin accessibility and regulates cardiac gene expression, we FACS-isolated GFP+ and GFP- cells from Tg(gata5:GFP) transgenic embryos in both control and Gata5/6 deficient embryos (injected wit...
ORGANISM(S): Danio rerio 
2021-12-31 | E-MTAB-10427 | biostudies-arrayexpress
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