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MetabolomicsA shotgun metabolomics approach to characterize the dissolved organic matter pool in the Samail Ophiolite aquifer
The process of serpentinization has been implicated in supporting life on both early Earth and other worlds in our Solar System. While numerous studies have provided clues to the survival strategies of microbial communities in serpentinizing environments on modern Earth, characterizing microbial act...
2023-03-02 | MTBLS6081 | MetaboLights
TranscriptomicsFunctional and Molecular Single-Cell Analyses Implicate PRDM14 in the Initiation of a Novel B-1 Cell Malignancy - Cut and Run experiments
Molecular mechanisms underlying high-risk subtypes of leukemia remain elusive. PR domain-containing 14 (Prdm14) is a potent oncogene implicated in the initiation of many cancers, including leukemia. Here, we interrogate the heterogeneity of Prdm14-expressing cell types in a mouse model of T-cell acu...
ORGANISM(S): Mus musculus 
2024-06-26 | E-MTAB-13159 | biostudies-arrayexpress
TranscriptomicsFunctional and Molecular Single-Cell Analyses Implicate PRDM14 in the Initiation of a Novel B-1 Cell Malignancy - Single Cell RNA sequencing experiments
Description: Molecular mechanisms underlying high-risk subtypes of leukemia remain elusive. PR domain-containing 14 (Prdm14) is a potent oncogene implicated in the initiation of many cancers, including leukemia. Here, we interrogate the heterogeneity of Prdm14-expressing cell types in a mouse model ...
ORGANISM(S): Mus musculus 
2024-06-29 | E-MTAB-13160 | biostudies-arrayexpress
GenomicsmRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription
We report a function of human mRNA decapping factors in control of transcription by RNA polymerase II. Decapping proteins Edc3, Dcp1a and Dcp2 and the termination factor TTF2 co-immunoprecipitate with Xrn2, the nuclear 5'-3' exonuclease torpedo that facilitates transcription termination at the 3' e...
ORGANISM(S): Homo sapiens 
2012-04-04 | E-GEOD-36185 | biostudies-arrayexpress
TranscriptomicsGlobal colorectal cancer gene expression in rats
The rat models of colorectal cancer (CRC), such as the azoxymethane (AOM) cancer-inducing model, are important tools for researching cancer initiation pathways. However, there is limited understanding of the expression pathways of underlying normal rat colonic epithelium and how this relates to hum...
ORGANISM(S): Rattus norvegicus 
2010-06-16 | E-GEOD-15184 | biostudies-arrayexpress
UnknownWhole genome sequence analyses of brain imaging measures in the Framingham Study.
Not available
S-EPMC5772158 | biostudies-literature
UnknownA first update on mapping the human genetic architecture of COVID-19.
Not available
S-EPMC9352569 | biostudies-literature
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