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MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
TranscriptomicsTranscription profiling of synthetic allopolyploid mature flower comparison in Senecio cambrensis
Not available
ORGANISM(S): Senecio cambrensis 
2006-09-19 | E-MAXD-5 | biostudies-arrayexpress
ProteomicsBarbed bone point chronology reveals an unexpected hiatus in the archaeology of Southern Scandinavia around 10,300 years BP
The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, which has informed prehistoric studies for more than a century. Central to this has been the first recognizably Mesolithic culture, the Maglemose (c. 11,000 - 8,000 BP), first described in 1903 w...
ORGANISM(S): Cervus elaphus (Red deer) Alces alces (Eurasian elk) 
2020-10-13 | PXD018050 | Pride
Palaeoproteomics Lc-ms Maldi-tof Cervids Archaeology Bone points 
MetabolomicsNon-redundant cardiolipin synthase family proteins shape lipid composition and stress resilience in Bacteroides fragilis

Gut-resident bacteria must withstand membrane-disrupting stresses such as bile acids to persist in the intestinal environment. The Bacteroidota are a dominant phylum of the human gut microbiota. However, the genes responsible for synthesis of membrane lipids in this phylum remain relatively uncha...

2026-10-06 | MTBLS11891 | MetaboLights
TranscriptomicsPerformance Evaluation of Commercial miRNA Expression Array Platforms
This data is part of a miRNA platform comparison study. We compared the performance characteristics of four commercial miRNA array technologies and found that all platforms performed well in separate measures of performance. The Ambion and Agilent platforms were more accurate, whereas the Illumina ...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-19248 | biostudies-arrayexpress
TranscriptomicsThe DNA Double-Strand Break Response Is Abnormal in Myeloblasts From Patients With Therapy-Related Acute Myeloid Leukemia
In order to examine if the upregulation of DNA repair genes on chromosome 8 was associated with the abnormal DSB phenotype observed in trisomy 8 (defined by array CGH or cytogenetics), we compared the mRNA levels of DNA repair genes on chromosome 8 in trisomy 8 t-AML patients versus normal t-AML gam...
ORGANISM(S): Homo sapiens 
2013-11-19 | E-GEOD-52478 | biostudies-arrayexpress
GenomicsCombinatorial transcription factor binding evolution in five placental mammals
Zoo-ChIP: Functional analysis of experimentally determined combinatorial transcription factor binding in multiple mammalian species
ORGANISM(S): Rattus norvegicus 
2014-09-27 | E-MTAB-1509 | biostudies-arrayexpress
MetabolomicsSex-specific effects of CD248 on metabolism and the adipose tissue lipidome

Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic consequences of loss of Cd248. Strikingly, we find these to be sex speci...

2023-01-05 | MTBLS6615 | MetaboLights
ProteomicsDOM composition changes in a warming peatland
Measure changes in dissolved organic matter composition and resulting microbial decomposition rates in an experimentally warmed peatland.
ORGANISM(S): unclassified Bacteria 
2021-05-27 | PXD019912 | Pride
Microbial decomposition Peatland Greenhouse gas production Dom 
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
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