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ProteomicsInteractomes of WT and H1069Q variants of ATP7B
The H1069Q substitution in the liver-specific copper transporter ATP7B represents the major cause of Wilson disease. The mutated ATP7B undergoes rapid degradation in the endoplasmic reticulum (ER) and fails to reach copper excretion compartments thus causing severe copper toxicosis in patients. Modu...
ORGANISM(S): Homo sapiens (Human) 
2020-12-11 | PXD016816 | Pride
Atp7b Wilson disease Copper 
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
ProteomicsOptimisation of sporosori purification and protein extraction techniques for the biotrophic protozoan plant pathogen Spongospora subterranea
Spongospora subterranea is a soil-borne plant pathogen responsible for economically significant root and powdery scab diseases of potato. However, Tthe obligate biotrophic nature of S. subterranea has made detailed study of the pathogen problematic. Here, we first compared the benefits of sporosori ...
ORGANISM(S): Spongospora sp. 
2021-09-09 | PXD019776 | Pride
Spongospora subterranea  sporosori  density gradient centrifugation  ludox  proteomics  s-trap. 
ProteomicsIn planta transcriptome and proteome profiles of Spongospora subterranea illuminates regulatory principles underlying host-pathogen interaction
Spongospora subterranea is an obligate biotrophic pathogen, causing a tremendous economic loss in the potato industry. Currently, there are no effective chemical or biological strategies for the control of S. subterranea. Understanding the gene regulation of pathogens in their host is dependent on m...
ORGANISM(S): Spongospora subterranea 
2022-02-17 | PXD027266 | Pride
Spongospora subterranea  potato  in planta analysis  transcriptomics  proteomics 
ProteomicsLarge-scale protein and phosphoprotein profiling to explore potato resistance mechanisms to Spongospora subterranea infection
Potato is one of the most important food crops for human consumption. The obligate biotrophic pathogen Spongospora subterranea infects potato roots and tubers, resulting in considerable loss of potato tuber yield and quality. A comprehensive understanding of how potato plants respond to S. subterran...
ORGANISM(S): Solanum tuberosum (Potato) 
2022-04-07 | PXD031529 | Pride
Powdery scab Proteomics Spongospora subterranea Phosphoproteomics Potato 
UnknownMowat-Wilson syndrome: growth charts.
Not available
S-EPMC7294656 | biostudies-literature
UnknownPharmacoproteomics pinpoints HSP70 interaction for correction of the most frequent Wilson disease-causing mutant of ATP7B.
Not available
S-EPMC7768786 | biostudies-literature
ProteomicsMulti-omics reveals mechanisms of potato resistance to powdery scab
The potato powdery scab agent Spongospora subterranea causes damage on the skin of tubers and induces root gall formation, precipitating considerable yield and quality losses. Currently, there are no effective chemical treatments for the control of powdery scabs. Understanding the inducible defence ...
ORGANISM(S): Solanum tuberosum (Potato) 
2022-08-12 | PXD029381 | Pride
Metabolomics  potato  proteomics  spongospora subterranea  transcriptomics 
ProteomicsProtein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts
Egg secretions fractionated by 2D electrophoresis and analysed by electrospray MS/MS
ORGANISM(S): Schistosoma mansoni (Blood fluke) 
2010-06-03 | PRD000251 | Pride
ProteomicsEnzymatic investigation of Spongospora subterranea zoospore attachment to roots of potato cultivars resistant or susceptible to powdery scab disease
For potato crops, host resistance is currently the most effective and sustainable tool to manage potato root and tuber diseases caused by the plasmodiophorid, Spongospora subterranea. Arguably, zoospore root attachment is the most critical phase of the pathogen infection, however, the mechanisms und...
ORGANISM(S): Solanum tuberosum (Potato) 
2023-03-11 | PXD037060 | Pride
Host resistance Cell wall modification Trypsin shaving Solanum tuberosum Spongospora subterranea Proteome 
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