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MetabolomicsIntegrated gut microbiome and lipidomic analyses in animal models of Wilson disease reveal a role of intestine ATP7B in copper-related metabolic dysregulation (Part 1)
Not available
ORGANISM(S): Mus musculus 
ST002423 | MetabolomicsWorkbench
MetabolomicsIntegrated gut microbiome and lipidomic analyses in animal models of Wilson disease reveal a role of intestine ATP7B in copper-related metabolic dysregulation (Part 3)
Not available
ORGANISM(S): Mus musculus 
ST002425 | MetabolomicsWorkbench
MetabolomicsIntegrated gut microbiome and lipidomic analyses in animal models of Wilson disease reveal a role of intestine ATP7B in copper-related metabolic dysregulation (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST002424 | MetabolomicsWorkbench
ProteomicsInteractomes of WT and H1069Q variants of ATP7B
The H1069Q substitution in the liver-specific copper transporter ATP7B represents the major cause of Wilson disease. The mutated ATP7B undergoes rapid degradation in the endoplasmic reticulum (ER) and fails to reach copper excretion compartments thus causing severe copper toxicosis in patients. Modu...
ORGANISM(S): Homo sapiens (Human) 
2020-12-11 | PXD016816 | Pride
Atp7b Wilson disease Copper 
GenomicsGene Expression in wild type and Atp7b-/- mice
Gene Expression in wild type and Atp7b-/- mice
PRJNA517037 | ENA
GenomicsRNA sequencing in Atp7b -/- mice under high-fat diet conditions
RNA sequencing in Atp7b -/- mice under high-fat diet conditions
PRJNA1249371 | ENA
GenomicsRNA Sequencing in LXR agonist fed Atp7b-/- mice (Wilson disease)
RNA Sequencing in LXR agonist fed Atp7b-/- mice (Wilson disease)
PRJNA728814 | ENA
ProteomicsProteomics exploration of the Atp7b-/- mouse plasma proteome: translational relevance for the diagnosis of Wilson’s disease
Wilson’s disease (WD) is a rare genetic disease caused by mutations in the ATP7B gene. These mutations impact the expression and/or function of the copper-transporting ATP7B protein, leading to massive toxic accumulation of copper in the liver and brain. Due to its low incidence and highly variable ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-04-14 | PXD011007 | Pride
Lc-srm Liver Biomarkers Wilson's disease Nanolc-ms/ms 
TranscriptomicsGene Expression in wild type and Atp7b-/- mice
Inactivating mutations in the copper transporter Atp7b result in Wilson’s disease. The Atp7b-/- mouse develops hallmarks of Wilson’s disease. The activity of several nuclear receptors is decreased in Atp7b-/- mice, and nuclear receptors are critical for maintaining metabolic homeostasis. Therefore, ...
ORGANISM(S): Mus musculus 
2020-04-14 | GSE125637 | GEO
TranscriptomicsRNA sequencing in Atp7b -/- mice under high-fat diet conditions
The aim of this study was to elucidate the impact of ATP7B deficiency on hepatic gene expression profiles in mice fed a high-fat diet. Systemic ATP7B-knockout (Atp7b-/-) mice on a C57BL/6J genetic background were generated via CRISPR/Cas9 technology and subjected to a high-fat, high-fructose, and hi...
ORGANISM(S): Mus musculus 
2025-05-05 | GSE294387 | GEO
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