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ProteomicsA Combined Shotgun and Targeted Mass Spectrometry Strategy for Breast Cancer Biomarker Discovery
Metastasizing breast cancer is an incurable disease. Thus, it is important to find proteins responsible for tumor dissemination, which may be used as biomarkers or treatment targets. In this study, we established the combination of a non-targeted LC-MS/MS discovery and a targeted LC-SRM verification...
ORGANISM(S): Homo sapiens (Human) 
2015-06-16 | PXD001685 | Pride
Breast cancer Shotgun Mrm Distant recurrence Srm 
UnknownHighly reliable LC-MS lipidomics database for efficient human plasma profiling based on NIST SRM 1950.
Not available
S-EPMC11607663 | biostudies-literature
UnknownDevelopment of a Chip/Chip/SRM platform using digital chip isoelectric focusing and LC-Chip mass spectrometry for enrichment and quantitation of low abundance protein biomarkers in human plasma.
Not available
S-EPMC3656385 | biostudies-literature
UnknownLC-SRM Combined With Machine Learning Enables Fast Identification and Quantification of Bacterial Pathogens in Urinary Tract Infections.
Not available
S-EPMC11532907 | biostudies-literature
MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
UnknownDevelopment, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum.
Not available
S-EPMC3866616 | biostudies-literature
OtherA Combined Shotgun and Targeted Mass Spectrometry Strategy for Breast Cancer Biomarker Discovery.
Data from ProteomeXchange, PXD ID: PXD001685. File: B08-07165_c.mzml. Published as part of J Proteome Res. 2015 Jun 5 . From the Abstract: {{i} ... Eighty breast tumors, stratified for estrogen receptor status and development of distant recurrence (DR - ), were collected. After enrichment of N-glyc...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320015681 | GPMDB
Resource Reanalysis 
ProteomicsComparison of targeted mass spectrometry techniques with an immunoassay: a case study for HSP90 alpha
We developed 2D-LC-MS/MS-based SRM and PRM assays to measure HSP90 alpha in serum and compared the results to a commercially available immunoassay (ELISA). Serum samples were trypsin-digested and fractionated by SCX chromatography prior to SRM and PRM measurements. PRM data obtained by high-resoluti...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD006615 | Pride
Srm Hsp90 Prm Scx Serum Shotgun Elisa Dda 
ProteomicsComparison of targeted mass spectrometry techniques with an immunoassay: a case study for HSP90 alpha
We developed 2D-LC-MS/MS-based SRM and PRM assays to measure HSP90 alpha in serum and compared the results to a commercially available immunoassay (ELISA). Serum samples were trypsin-digested and fractionated by SCX chromatography prior to SRM and PRM measurements. PRM data obtained by high-resoluti...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD006569 | Pride
Srm Hsp90 Prm Scx Serum Elisa 
ProteomicsProteomics exploration of the Atp7b-/- mouse plasma proteome: translational relevance for the diagnosis of Wilson’s disease
Wilson’s disease (WD) is a rare genetic disease caused by mutations in the ATP7B gene. These mutations impact the expression and/or function of the copper-transporting ATP7B protein, leading to massive toxic accumulation of copper in the liver and brain. Due to its low incidence and highly variable ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-04-14 | PXD011007 | Pride
Lc-srm Liver Biomarkers Wilson's disease Nanolc-ms/ms 
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