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ProteomicsSerum integrative omics reveals the landscape of human diabetic kidney disease
Diabetic kidney disease (DKD) is the most common microvascular complication of type 2 diabetes mellitus (2-DM). Currently, urine and kidney biopsy specimens are the major clinical resources for DKD diagnosis. The diagnostic values of blood in monitoring the onset and progression of DKD have not been...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-22 | MSV000087487 | MassIVE
ProteomicsIdentification of root surface proteins from potato strains susceptible and resistant to Spongospora subterranea infection
This project is aiming to identify specific root surface proteins from susceptible and resistant potato strains and identify those factors responsible for Spongospora subterranea zoospore binding.
ORGANISM(S): Solanum tuberosum (Potato) 
2022-10-13 | PXD022502 | Pride
Spongospora subterranea  zoospore  disease resistance  potato 
ProteomicsLysosomal alterations and altered electrophysiological activity in atypical juvenile neuronal ceroid lipofuscinoses (CLN3 1 kb deletion, E295K) patient-derived cortical neurons
Juvenile neuronal ceroid lipofuscinoses (JNCL) is a lysosomal storage disorder associated with fatal neurodegeneration that is caused by mutations in CLN3. Most individuals with JNCL carry at least one allele with 1 kb deletion in CLN3 which results in the deletion of exons 7 and 8. There is a need ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-07 | PXD032191 | Pride
Lysosomal storage disorder Neurological disease models Juvenile neuronal ceroid lipofuscinoses Human induced pluripotent stem cells 
ProteomicsSeabirds in crisis: plastic ingestion induces proteomic signatures of multi-organ failure and neurodegeneration
Understanding plastics’ harmful impacts has been hampered by the application of overly simplistic tools, mostly focusing on a single response variable which limits our ability to detect changes in wildlife health. Adopting a data-driven, proteomics approach, we assessed changes in 745 proteins in a ...
ORGANISM(S): Fulmarus glacialis 
2025-03-27 | PXD057275 | Pride
Wildlife Proteomics Microplastics 
Proteomics¬¬¬Seabirds in crisis: plastic ingestion induces proteomic signatures of multi-organ failure and neurodegeneration
Understanding plastics’ harmful impacts has been hampered by the application of overly simplistic tools, mostly focusing on a single response variable which limits our ability to detect changes in wildlife health. Adopting a data-driven, proteomics approach, we assessed changes in 745 proteins in a ...
ORGANISM(S): Ardenna carneipes 
2025-03-27 | PXD046876 | Pride
Shearwater Wildlife Proteomics Microplastics 
ProteomicsMulti-omics reveals mechanisms of potato resistance to powdery scab
The potato powdery scab agent Spongospora subterranea causes damage on the skin of tubers and induces root gall formation, precipitating considerable yield and quality losses. Currently, there are no effective chemical treatments for the control of powdery scabs. Understanding the inducible defence ...
ORGANISM(S): Solanum tuberosum (Potato) 
2022-08-12 | PXD029381 | Pride
Metabolomics  potato  proteomics  spongospora subterranea  transcriptomics 
ProteomicsOptimisation of sporosori purification and protein extraction techniques for the biotrophic protozoan plant pathogen Spongospora subterranea
Spongospora subterranea is a soil-borne plant pathogen responsible for economically significant root and powdery scab diseases of potato. However, Tthe obligate biotrophic nature of S. subterranea has made detailed study of the pathogen problematic. Here, we first compared the benefits of sporosori ...
ORGANISM(S): Spongospora sp. 
2021-09-09 | PXD019776 | Pride
Spongospora subterranea  sporosori  density gradient centrifugation  ludox  proteomics  s-trap. 
ProteomicsSalmon liver proteomics - Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature
Atlantic salmon production in Tasmania (Southern Australia) occurs near the upper limits of the species thermal tolerance. Summer water temperatures can average over 19°C over several weeks and have negative effects on performance and health. Liver tissue exerts important metabolic functions in ther...
ORGANISM(S): Salmo salar (Atlantic salmon) 
2018-03-01 | PXD004985 | Pride
Thermal stress Aquaculture Proteomics 
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
ProteomicsEnzymatic investigation of Spongospora subterranea zoospore attachment to roots of potato cultivars resistant or susceptible to powdery scab disease
For potato crops, host resistance is currently the most effective and sustainable tool to manage potato root and tuber diseases caused by the plasmodiophorid, Spongospora subterranea. Arguably, zoospore root attachment is the most critical phase of the pathogen infection, however, the mechanisms und...
ORGANISM(S): Solanum tuberosum (Potato) 
2023-03-11 | PXD037060 | Pride
Host resistance Cell wall modification Trypsin shaving Solanum tuberosum Spongospora subterranea Proteome 
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