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ProteomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domainThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domain
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...
ORGANISM(S): Homo sapiens (Human) 
2023-01-14 | PXD034833 | Pride
Winged helix Histone acetylation Cpg islands Kat6a Chromatin 
ProteomicsMORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain
Human acetyltransferases MOZ and MORF are implicated in chromosomal translocations associated with aggressive leukemias. Oncogenic translocations involve the far amino terminus of MOZ/MORF, the function of which remains unclear. Here, we identified and characterized two structured winged helix domai...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036192 | Pride
Morf moz cpg islands 
UnknownA Novel Family of Winged-Helix Single-Stranded DNA-Binding Proteins from Archaea.
Not available
S-EPMC8998557 | biostudies-literature
UnknownStructure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis.
Not available
S-EPMC4000134 | biostudies-literature
UnknownImportins recognize the winged-helix fold of ETS transcription factors to mediate nuclear import.
Not available
S-EPMC12803118 | biostudies-literature
UnknownSolution NMR structures reveal unique homodimer formation by a winged helix-turn-helix motif and provide first structures for protein domain family PF10771.
Not available
S-EPMC3654790 | biostudies-literature
GenomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [RNA-seq]
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [RNA-seq]
PRJNA849946 | ENA
TranscriptomicsTranscription profiling of mouse Ngn3 expressing cells and endocrine pancreatic cells from wild type and Ngn3 mutant animals at day 15 of embryonic development
The basic helix-loop-helix transcription factor Neurogenin3 (Ngn3/Neurog3) is expressed in endocrine progenitor cells in the embryonic mouse pancreas. Ngn3 controls endocrine cell fate decisions. Ngn3 deficient mice do not develop any pancreatic endocrine cells, including insulin producing beta cel...
ORGANISM(S): Mus musculus 
2009-12-03 | E-CBIL-48 | biostudies-arrayexpress
UnknownDeciphering the protein-DNA code of bacterial winged helix-turn-helix transcription factors.
Not available
S-EPMC10662834 | biostudies-literature
GenomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [ChIP-seq]
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [ChIP-seq]
PRJNA849940 | ENA
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