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ProteomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domainThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domain
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...
ORGANISM(S): Homo sapiens (Human) 
2023-01-14 | PXD034833 | Pride
Winged helix Histone acetylation Cpg islands Kat6a Chromatin 
ProteomicsMORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain
Human acetyltransferases MOZ and MORF are implicated in chromosomal translocations associated with aggressive leukemias. Oncogenic translocations involve the far amino terminus of MOZ/MORF, the function of which remains unclear. Here, we identified and characterized two structured winged helix domai...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036192 | Pride
Morf moz cpg islands 
GenomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [RNA-seq]
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [RNA-seq]
PRJNA849946 | ENA
GenomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [ChIP-seq]
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [ChIP-seq]
PRJNA849940 | ENA
UnknownThe winged helix domain of MORF binds CpG islands and the TAZ2 domain of p300.
Not available
S-EPMC10946326 | biostudies-literature
TranscriptomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [RNA-seq]
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...
ORGANISM(S): Mus musculus 
2022-12-20 | GSE206273 | GEO
GenomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [ChIP-seq]
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...
ORGANISM(S): Homo sapiens 
2022-12-20 | GSE206272 | GEO
UnknownCharacterization of winged helix domain fusion endonucleases as N6-methyladenine-dependent type IV restriction systems.
Not available
S-EPMC11037411 | biostudies-literature
ProteomicsA novel domain essential for interdomain cooperativity in binding of a Rep protein to DNA.
A very important feature of replication initiation proteins is the ability to bind to DNA via a characteristic domain. Usually, one or two DNA-binding domains can be distinguished within each initiator. In this work, we specified a new family of replication initiation proteins (the TrfA-like protein...
ORGANISM(S): Escherichia coli 
2021-09-08 | PXD013286 | Pride
Dna replication initiation Trfa Rep proteins Mass spectrometry Dna binding domain Winged helix domain Plasmid rk2 
UnknownSolution NMR structures reveal unique homodimer formation by a winged helix-turn-helix motif and provide first structures for protein domain family PF10771.
Not available
S-EPMC3654790 | biostudies-literature
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