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MetabolomicsBiomonitoring of mycotoxins and exposomics-informed profiling in extreme preterm infants from the NeoVIP cohort

Extremely premature infants are a highly vulnerable patient group that might be exposed to a vast number of dietary and environmental contaminants, which may impact their health trajectories. This study assessed xenobiotic exposures in 26 extremely premature infants, with a special focus on dieta...

2026-06-23 | MTBLS14832 | MetaboLights
TranscriptomicsNickel-induced contact dermatitis induce changes in human skin transcriptome over 96 hours
We aimed to characterize transcriptomic changes over time (baseline, 2 hours, 48 hours and 96 hours) after nickel-induced contact dermatitis in 6 human probands. As a contrast, 7 patients with SLS-induced irritant contact dermatitis were included. Therefore, the patch tests were applied onto the bac...
ORGANISM(S): Homo sapiens 
2020-05-01 | E-MTAB-8945 | biostudies-arrayexpress
MetabolomicsNext-generation biomonitoring of the early-life chemical exposome in neonatal and infant development

Exposure to synthetic and natural chemicals is a major environmental risk factor in the etiology of many chronic diseases. Investigating complex co-exposures is necessary for a holistic assessment in exposome-wide association studies. In this work, a sensitive liquid chromatography-tandem mass sp...

2023-10-26 | MTBLS2442 | MetaboLights
TranscriptomicsIntegrative analysis of miRNA/mRNA expression patterns in allergic contact dermatitis
Allergic and irritant contact dermatitis induces different immunological cascades, involving a plethora of immune cells as well as keratinocytes. This highly interwoven network is regulated by miRNAs. However, which miRNAs are involved during allergic- and irritant-induced contact dermatitis is not ...
ORGANISM(S): Homo sapiens 
2020-07-01 | E-MTAB-9051 | biostudies-arrayexpress
TranscriptomicsMachine learning driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis
Allergic and irritant contact dermatitis induces different immunological cascades, involving a plethora of immune cells as well as keratinocytes. 96 patients were investigated using mRNA microarray experiments, of which 88 passed our QC criteria. Patients were topically exposed to allergens (nickel ...
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-9501 | biostudies-arrayexpress
MetabolomicsDried blood spots analysis for targeted and non-targeted exposomics

Dried blood spots (DBS) are an established sample type, widely used in newborn screening programs for monitoring metabolic diseases. Their minimally invasive nature offers great promise for assessing chemical exposures, particularly during early life stages and in large-scale epidemiological stud...

2025-10-09 | MTBLS13065 | MetaboLights
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