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Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering - TCR156wt and S32M
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