Sort   by:  
 Page size 
ProteomicsWNK1 signalling regulates amino acid transport and mTORC1 activity to sustain AML growth
The lack of curative therapies for acute myeloid leukaemia (AML) remains an ongoing challenge despite recent advances in the understanding of the molecular basis of the disease. Here we identify the WNK1-OXSR1/STK39 pathway as a previously uncharacterised dependency in AML. We show that genetic depl...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-02 | PXD041902 | Pride
Wnk1 Phosphoproteomics Aml Mtor 
GenomicsWNK1 enforces macrophage lineage fidelity
WNK1 enforces macrophage lineage fidelity
PRJNA804425 | ENA
GenomicsTranscriptomics changes upon WNK1 knockdown in JJN3 cells
Transcriptomics changes upon WNK1 knockdown in JJN3 cells
PRJNA1024367 | ENA
GenomicsCD4+ T cell activation in absence of WNK1
CD4+ T cell activation in absence of WNK1
PRJNA830460 | ENA
GenomicsMeiotic completion of the spermatocytes requires the kinase WNK1
Meiotic completion of the spermatocytes requires the kinase WNK1
PRJNA979256 | ENA
GenomicsAnalysis of anti-CD3e-induced transcriptional changes in WNK1-deficient thymocytes
Analysis of anti-CD3e-induced transcriptional changes in WNK1-deficient thymocytes
PRJNA561601 | ENA
GenomicsTargeting WNK1 suppresses acute myeloid leukemia progression and enhances sensitivity to venetoclax
Targeting WNK1 suppresses acute myeloid leukemia progression and enhances sensitivity to venetoclax
PRJNA1470572 | ENA
TranscriptomicsWNK1 enforces macrophage lineage fidelity
The appropriate development of myeloid progenitors into macrophages, the body’s professional phagocyte, is essential for organismal development, especially in mammals1. This dependence is exemplified by the observation that loss-of-function mutation in colony stimulating factor 1 receptor (CSF1R) re...
ORGANISM(S): Mus musculus 
2024-02-06 | GSE196336 | GEO
GenomicsscRNA-seq of aortas from mice with Wnk1 deletion in vascular smooth muscle cells (experiment 1)
scRNA-seq of aortas from mice with Wnk1 deletion in vascular smooth muscle cells (experiment 1)
PRJNA1104151 | ENA
ProteomicsWNK1-specific phosphorylation sites in TBC1D1 and TBC1D4 modulate cell surface expression of GLUT1
Glucose uptake by mammalian cells is a key mechanism to maintain cell and tissue homeostasis and relies mostly on plasma membrane-localized glucose transporter proteins (GLUTs). Two main cellular mechanisms regulate GLUT proteins in the cell: first, expression of GLUT genes is under dynamic transcri...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD016218 | Pride
Human Phosphorylation 
Sort   by:  
 Page size