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TranscriptomicsSingle cell RNA-sequencing experiment of human embryonic stem cells (hESCs) upon Wnt stimulation treatment at three time points (4 hours, 24 hours and 3 days)
Wnt/b-catenin signalling is an evolutionarily conserved mechanism for cell-cell communication implicated in both developmental processes and diseases such as cancer. A main part of this signalling pathway is the stabilization and nuclear translocation of b-catenin, driving the transcriptional regula...
ORGANISM(S): Homo sapiens 
2023-02-23 | E-MTAB-12598 | biostudies-arrayexpress
ProteomicsNotch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
The Wnt-signalling pathway is one of the core de-regulated pathways in chronic lymphocytic leukemia (CLL), activated in a subset of patients by somatic coding mutations. Here we describe an alternative mechanism of Wnt-activation in malignant B cells, mediated by Notch2 activity in mesenchymal strom...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-19 | PXD010401 | Pride
Wnt Notch Cll Plasma membrane 
TranscriptomicsRNA-seq experiment at four time points in HEK293 and hESC cells, assessing the time-resolved response on gene expression upon Wnt/β-catenin signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin-driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes human...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12075 | biostudies-arrayexpress
TranscriptomicsChIP-seq experiment of mouse embryonic stem cells (mESCs), assessing beta-catenin DNA binding in wild type mESCs and TCF/LEF quadruple knock-out mESCs.
Mouse embryonic stem cells (mESCs), derived from pre-implantation blastocyst cells, can be maintained in vitro in defined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory factor (LIF), which act synergistically to promote self-renewal ...
ORGANISM(S): Mus musculus 
2021-06-15 | E-MTAB-10575 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiment of mouse embryonic stem cells (mESCs), comparing TCF/LEF quadruple knock-out cells with wild type cells
Mouse embryonic stem cells (mESCs), derived from pre-implantation blastocyst cells, can be maintained in vitro in defined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory factor (LIF), which act synergistically to promote self-renewal ...
ORGANISM(S): Mus musculus 
2021-06-15 | E-MTAB-10564 | biostudies-arrayexpress
TranscriptomicsTemporal activation of WNT/ β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth
Despite advances in the systemic treatment of patients with metastatic melanoma using immune checkpoint and tyrosine kinase inhibitors (TKI), the majority of stage IV melanoma patients eventually succumb to the disease. We have previously identified the transcription factor Sox10 as a crucial player...
ORGANISM(S): Homo sapiens 
2021-01-01 | GSE146415 | GEO
UnknownRole that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis.
Not available
S-EPMC1142569 | biostudies-literature
UnknownNotch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia.
Not available
S-EPMC6155045 | biostudies-literature
GenomicsSingle cell RNA-sequencing experiment of human embryonic stem cells (hESCs) upon Wnt stimulation treatment at three time points (4 hours, 24 hours and 3 days)
Single cell RNA-sequencing experiment of human embryonic stem cells (hESCs) upon Wnt stimulation treatment at three time points (4 hours, 24 hours and 3 days)
PRJEB59567 | ENA
ProteomicsRegulation of proteome by the proteasome upon ER stress
HeLa cells were with Tunicamycin or Thapsigargin for 8 hours in the presence or absence of MG132 or untreated. Cells were lysed by addition of HEPES 50 mM pH7.9 with 5% SDS. Proteins were precipitated with methanol/chloroforme and the proteins were resolubilized in 8 M Urea and digested with trypsin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-04-30 | MSV000083736 | MassIVE
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