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MetabolomicsTime-Restricted Feeding Orchestrates Astrocytic Metabolic Reprogramming via the Wnt Pathway to Alleviate Sevoflurane-Induced Neural Injury

Perioperative neurocognitive disorders (PND) pose a significant challenge for aging surgical patients, with sevoflurane anesthesia being an identified risk factor. Time-restricted feeding (TRF), a dietary regimen, shows promise in mitigating age-related cognitive decline, but its efficacy and mec...

2026-02-17 | MTBLS13891 | MetaboLights
OtherHuwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.
Data from ProteomeXchange, PXD ID: PXD000781. File: KN_Ubi_endo_130528_minus_fr_65min_01.mzml. Published as part of Sci Signal. 2014 Mar 18;7(317):ra26 . From the Abstract: {{i}} In human embryonic kidney 293T cells, knockdown of the EEL-1 homolog Huwe1 enhanced the activity of a Wnt reporter in ce...
ORGANISM(S): Homo_sapiens_viruses, Human,one_off 
GPM32310000423 | GPMDB
Resource Reanalysis 
TranscriptomicsDistinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway
Medulloblastoma is a malignant brain tumor that occurs predominantly in children. Current risk stratification based on the clinical parameters is inadequate for accurate prognostication. In order to get a better understanding of medulloblastoma biology, miRNA profiling of medulloblastomas was carrie...
ORGANISM(S): Homo sapiens 
2012-10-27 | E-GEOD-41842 | biostudies-arrayexpress
TranscriptomicsWnt signaling involved in mouse myoblast differentiation
Wnt/M-NM-2-catenin signaling is involved in various aspects of skeletal muscle development and regeneration. In addition, Wnt3a and M-NM-2-catenin are required for muscle-specific gene transcription in embryonic carcinoma cells and satellite-cell proliferation during adult skeletal muscle regenerati...
ORGANISM(S): Mus musculus 
2011-07-15 | E-GEOD-30077 | biostudies-arrayexpress
TranscriptomicsButyrate Induced Changes in Wnt Signaling-Specific Gene Expression in Colorectal Cancer Cells
To identify Wnt target genes whose expression is differentially modulated by butyrate Doxycycline inducible DN-Tcf4 expression was used to repress Wnt signaling, cells were treated with butyrate or mock treated. Genes differentially regulated by butyrate in the absence of doxycycline but not in its...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-54127 | biostudies-arrayexpress
TranscriptomicsBarx2 and Pax7 have antagonistic functions in regulation of Wnt signaling and satellite cell differentiation
The canonical Wnt signaling pathway is critical for myogenesis and can induce muscle progenitors to switch from proliferation to differentiation; how Wnt signals integrate with muscle specific regulatory factors in this process is poorly understood. We previously demonstrated that the Barx2 homeobox...
ORGANISM(S): Mus musculus 
2015-10-22 | E-GEOD-53398 | biostudies-arrayexpress
ProteomicsWNT7 Promotes Proliferation of Pancreatic Progenitor Cells Differentiated from Human Pluripotent Stem Cells through Non-Canonical Wnt Signaling Pathway
A small molecule, AT7867, promotes proliferation of human pluripotent stem cell-derived pancreatic progenitor cells (PPCs), yet detailed mechanisms of its proliferative effect were not fully understood. Here, we performed cell-based siRNA screening on a subset of genes to reveal that WNT7B is a grow...
ORGANISM(S): Homo Sapiens (human) 
2022-03-27 | PXD018222 | JPOST Repository
ProteomicsWNT7 Promotes Proliferation of Pancreatic Progenitor Cells Differentiated from Human Pluripotent Stem Cells through Non-Canonical Wnt Signaling Pathway
A small molecule, AT7867, promotes proliferation of human pluripotent stem cell-derived pancreatic progenitor cells (PPCs), yet detailed mechanisms of its proliferative effect were not fully understood. Here, we performed cell-based siRNA screening on a subset of genes to reveal that WNT7B is a grow...
ORGANISM(S): Homo Sapiens (human) 
2021-07-01 | PXD018221 | JPOST Repository
TranscriptomicsProfile of microRNA during adipogenesis regulating by microRNA and WNT signaling
To investigate miRNAs that implicate the process of adipogenesis by interacting with canonical Wnt/β-catenin signaling pathway, we constructed two cell models at first, and then investigated the expression profile of microRNAs by using Microarray. Based on the data of high throughput microarray, we...
ORGANISM(S): Mus musculus 
2010-04-22 | E-GEOD-19421 | biostudies-arrayexpress
TranscriptomicsRole of TAZ as mediator of Wnt signaling (SW480)
To investigate the role of TAZ downstream of the abberrant Wnt signaling in CRC cells, we compared the expression profiles of parental SW480 cells (empty vector) transfected with siControl, siTAZ, sibeta-catenin or reconstituted with wild type APC and transfected with siControl Keywords: expression...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-39904 | biostudies-arrayexpress
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