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TranscriptomicsAnalysis of Culex quinquefasciatus responses to WNV infection
Analysis of Culex quinquefasciatus responses to West Nile virus (WNV) infection at 7 and 14 days after ingestion of infected blood in the gut and carcass tissues. Comparison of WNV-infected to non-infected carcass and gut samples.
ORGANISM(S): Culex quinquefasciatus 
2011-11-01 | E-GEOD-23045 | biostudies-arrayexpress
TranscriptomicsMouse popliteal lymph node transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [mRNA]
The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in mouse cortex infected with wild-type West Nile virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Mice are inoculated with WNV in both hind footpads at a dos...
ORGANISM(S): Mus musculus 
2016-03-15 | E-GEOD-78888 | biostudies-arrayexpress
TranscriptomicsMouse cortex transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [WCT001_miRNA]
The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in mouse cortex infected with wild-type West Nile virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Mice were inoculated with WNV intracranially at a dose of 1...
ORGANISM(S): Mus musculus 
2016-03-12 | E-GEOD-77161 | biostudies-arrayexpress
TranscriptomicsIdentification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis
Background: West Nile virus is an emerging infection of biodefense concern and there are no available treatments or vaccines. Here we used a high-throughput method based on a novel gene expression analysis, RNA-Seq, to give a global picture of differential gene expression by primary human macrophage...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-40718 | biostudies-arrayexpress
TranscriptomicsMouse cerebellum transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [WCB001_mRNA]
The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in mouse cerebellum infected with wild-type West Nile virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Mice were inoculated with WNV intracranially at a dose ...
ORGANISM(S): Mus musculus 
2016-02-15 | E-GEOD-77192 | biostudies-arrayexpress
TranscriptomicsMouse cerebellum transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [WCB001_microRNA]
The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in mouse cerebellum infected with wild-type West Nile virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Mice were inoculated with WNV intracranially at a dose ...
ORGANISM(S): Mus musculus 
2016-02-21 | E-GEOD-77160 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of mice with good and poor spatial learning during West Nile virus recovery
Greater than 50% of patients who survive neuroinvasive West Nile virus (WNV), a mosquito-borne, positive-sense strand flavivirus, exhibit cognitive sequelae including memory impairments which may last several years. High survival rates from WNV neuroinvasive disease (WNND) (>90%) have led to hundred...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-72139 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of 3D model of blood-brain barrier exposed to West Nile virus (WNV)
Using RNA sequencing to map differentially expressed genes in the 3D model of the blood-brain barrier ( composed of human brain endothelial cells, human astrocytes, and human pericytes) challenged with WNV.
ORGANISM(S): Homo sapiens 
2021-01-01 | E-MTAB-9754 | biostudies-arrayexpress
TranscriptomicsIRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling
Myeloid dendritic cells from WT, Irf3-/-xIrf7-/-, Irf3-/-xIrf5-/-xIrf7-/-, Mavs-/- (IPS1-/-)and Ifnar-/- mice were infected with West Nile virus to assess the contributions of specific signaling and transcription factors in initiating the antiviral response RPMI + rmGM-CSF purified bone marrow deriv...
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-41355 | biostudies-arrayexpress
TranscriptomicsExpression data of Brain CD45+ cells from WT and STI knockout mice after WNV infection
West Nile virus (WNV) is the most important cause of endemic encephalitis in the USA. Strikingly, only a small percentage of patients develop clinical disease and of these patients, approximately 1 out of 150 patients develops encephalitis. The basis for this great variability in disease outcome is ...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-79417 | biostudies-arrayexpress
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