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TranscriptomicsUC San Diego_Friedmann_Kang_ESD3_Neuronal Differentiation
The overall gene expression pattern of HPRT knockdown murine D3 stem cells during neuronal differentiation was invesitigated by microarray based gene expression analysis and the results were interpreted by GO, GSEA and signaling pathway analyses with GeneSpring GX and PANTHER Classification System. ...
ORGANISM(S): Mus musculus 
2012-11-22 | E-GEOD-42453 | biostudies-arrayexpress
TranscriptomicsUC San Diego_Friedmann_Kang_Human fibroblast knockdown
To characterize mechanisms responsible for the CNS dopamine deficiency and the resulting neuropathology caused by deficiency of the housekeeping purine salvage function hypoxanthine guanine phospho- ribosyltransferase (HPRT) in the Lesch Nyhan Disease (LND), we have used microarray-based methods of ...
ORGANISM(S): Homo sapiens 
2010-09-25 | E-GEOD-24345 | biostudies-arrayexpress
TranscriptomicsGene expression in IL-10-deficient and wild-type mice following Citrobacter rodentium infection
To further understand immune mechanims involved in regulating intestinal inflammation, we employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential of regulating inflammation in the absence of IL-10. Whole colon tissue from IL-10-deficient and...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55812 | biostudies-arrayexpress
TranscriptomicsDIDS protects against neuronal injury
Using long-oligo beadschip arrays, we examined the global gene expression profile in cultured hippocampal slices under the simulated ischemic condition with and without the presence of DIDS . Control-ACSF: cultured hippocampal slices were incubated with ACSF for 2 hours and were analysed on whole-ge...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-12426 | biostudies-arrayexpress
TranscriptomicsExpression profile of WT and IKKb(EE)IEC epithelial cells (IEC)
To investigate NF-kB-driven gene expression in IEC, we performed microarray analysis from enterocytes of mice that express a constitutively active form of IKKb in intestinal epithelial cells Total RNA was prepared from enterocytes obtained from small intestines of IKKb(EE)IEC and WT littermates. Tw...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-29701 | biostudies-arrayexpress
TranscriptomicsGene expression in IL-17RA-deficient and wild-type mice following Giardia muris infection
To elucidate IL-17A-dependent immune mechanims involved in regulating host defense, we employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential of regulating protective immunity that failed to be upregulated in the absence of IL-17RA signalin...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-68868 | biostudies-arrayexpress
ProteomicsAre you also what Your Mother Eats? Distinct Proteomic Portrait as a Result of Maternal High-Fat Diet in the Cerebral Cortex of the Adult Mouse.
Background: Epidemiological studies suggest an association between maternal obesity and adverse neurodevelopmental outcomes in offspring. Objective: To compare the global proteomic portrait in the cerebral cortex between mice born to mothers on a high-fat or control diet who themselves were fed a h...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-29 | PXD001540 | Pride
2d lc-ms/ms Proteomics Brain Obesity High-fat diet Cerebral cortex Itraq Maternal 
UnknownComparison of St John's wort and imipramine for treating depression: randomised controlled trial.
Not available
S-EPMC27467 | biostudies-literature
TranscriptomicsExpression profile of colon crypts from WT and GMCSF-/- mice with or without DSS treatment
To discover possible molecular mechanisms mediated by GM-CSF that may be involved in regeneration of the colon epithelium after DSS-induced injury we performed whole-genome wide mRNA microchip analysis of isolated crypt epithelial cells from unchallenged and DSS-challenged WT and GM-CSF-/- mice. Tot...
ORGANISM(S): Mus musculus 
2012-11-21 | E-GEOD-42173 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression in HIV-Infected Individuals Following ART.
A paired analysis of peripheral blood mononuclear cells (PBMCs) isolated before and after antiretroviral therapy (ART) from a robust number of HIV-infected patients (N=36). Results identify a total of 4,157 DEGs following ART in HIV-infected participants and the transition from a period of active vi...
ORGANISM(S): Homo sapiens 
2013-09-10 | E-GEOD-44228 | biostudies-arrayexpress
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