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GenomicsNHLBI Family Heart Study (FamHS-Visit1 and FamHS-Visit2)

The Family Heart Study (FamHS) was funded by the National Heart, Lung, and Blood Institute (NHLBI). It was begun in 1992 with the ascertainment of 1,200 families, half randomly sampled, and half selected because of an excess of coronary heart disease (CHD) or risk factor abnormalities as compared...

phs000221.v1.p1 | EGA
UnknownConsumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians.

Background

Recent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown.

Objective

We investigated the associ...
S-EPMC4625584 | biostudies-literature
UnknownGenome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts.

Background

Regular fish and omega-3 consumption may have several health benefits and are recommended by major dietary guidelines. Yet, their intakes remain remarkably variable both within and across populations, which could partly owe to genetic influences.

Objective

To identify commo...
S-EPMC5728559 | biostudies-literature
UnknownGene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry.
Obesity is highly heritable. Genetic variants showing robust associations with obesity traits have been identified through genome-wide association studies. We investigated whether a composite score representing healthy diet modifies associations of these variants with obesity traits. Totally, 32 bod...
S-EPMC4512626 | biostudies-literature
UnknownFTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.
FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-sc...
S-EPMC4271061 | biostudies-literature
UnknownCNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.
There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to 191,161 adult samples from 26 cohorts. The study reveals five CNV associations at ...
S-EPMC5622064 | biostudies-literature
UnknownGene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein ch...
S-EPMC10651736 | biostudies-literature
UnknownA Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-w...
S-EPMC5985266 | biostudies-literature
UnknownDiscovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.
Although many loci have been associated with height in European ancestry populations, very few have been identified in African ancestry individuals. Furthermore, many of the known loci have yet to be generalized to and fine-mapped within a large-scale African ancestry sample. We performed sex-combin...
S-EPMC8059339 | biostudies-literature
UnknownGenome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to ...
S-EPMC4388784 | biostudies-literature
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