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ProteomicsDual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins
Exposure to heat stress triggers a well-defined acute response marked by HSF1-dependent transcriptional upregulation of heat shock proteins. Cells allowed to recover acquire thermotolerance, but this adaptation is poorly understood. By quantitative proteomics, we discovered selective upregulation of...
ORGANISM(S): Homo sapiens (Human) 
2021-05-02 | PXD025123 | Pride
Heat shock protein 70 Esophageal cancer Ubiquitin proteasome system (ups) Stress response 
ProteomicseIF3 subunit-specific mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
eIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNAeIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNA-selective functions of individual subunits ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-14 | PXD034084 | Pride
Eif3 
ProteomicsDiscovery of human breast cancer cell MCF7 heat induced proteins by LC-MS/MS
Co-translational degradation via the ubiquitin-proteasome system mediates quality control of 15 – 25% of nascent proteins, a proportion that is known to increase dramatically under proteotoxic stress conditions. Whereas the ubiquitylation machinery involved has been characterized, mechanisms coordin...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020140 | Pride
Chaperones Heat shock response Proteasome Lc-ms/ms 
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