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GenomicsProteogenomics analysis reveals specific genomic orientations at distal regulatory regions composed by non-canonical histone variants
Histone variants (H3.1, H3.3, H2A, and macroH2A) were studied about their proteomic and genomic distribution in Hela cells HeLa S3 cells stably expressing either FLAG-tagged H3.1, and H3.3 were grown in suspension in Joklik media containing 10% newborn calf serum (Hyclone), 1% GlutaMAX (Invitrogen),...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-64652 | biostudies-arrayexpress
GenomicsHistone H4 acetylation and epigenetic reader Brd4 are critial regulators of pluripotency in embryonic stem cells
Histone H4ac and Brd4 are critical for ESCs 12 samples: 2 replicates for each ChIP, 2 replicates for each input sample.
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-76760 | biostudies-arrayexpress
GenomicsSpecific mitotic chromatin association of the major notch effector RBPJ and its implication for transcriptional memory
From the cell-based investigation, RBPJ is one of the few proteins retained on chromatin during cell division. ChIP-seq experiments were performed to understand the binding pattern of RBPJ between interphase and mitosis and to identify the genes requiring RBPJ binding for the maintenance of transcri...
ORGANISM(S): Mus musculus 
2014-05-14 | E-GEOD-45889 | biostudies-arrayexpress
GenomicsHDAC3-dependent regulation of H3K9 acetylation in IECs
The development and severity of inflammatory bowel diseases (IBD) and other chronic inflammatory conditions can be influenced by host genetic and environmental factors, including signals derived from commensal bacteria. However, the mechanisms that integrate these diverse cues remain undefined. Her...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-50453 | biostudies-arrayexpress
GenomicsEpigenome in brown and white adipose tissue
For comparative epigenomic analysis of brown fat and white fat in mice, H3K27ac and PolII ChIP-seq were performed in each depot. H3K27ac histone modification and PolII transcription profiles in mouse brown and white adipose tissues
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-63964 | biostudies-arrayexpress
TranscriptomicsEbf2 is a selective marker of brown and beige adipogenic precursor cells (RNA-seq)
Brown adipocytes, muscle and dorsal dermis descend from precursor cells in the dermomyotome, but the factors that regulate commitment to the brown adipose lineage are unknown. Here, we prospectively isolated and determined the molecular profile of embryonic brown preadipose cells. Brown adipogenic p...
ORGANISM(S): Mus musculus 
2014-09-16 | E-GEOD-60441 | biostudies-arrayexpress
TranscriptomicsEbf2 is a selective marker of brown and beige adipogenic precursor cells (Microarray)
Brown adipocytes, muscle and dorsal dermis descend from precursor cells in the dermomyotome, but the factors that regulate commitment to the brown adipose lineage are unknown. Here, we prospectively isolated and determined the molecular profile of embryonic brown preadipose cells. Brown adipogenic p...
ORGANISM(S): Mus musculus 
2014-09-16 | E-GEOD-60442 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of human pancreatic endocrine cells from Juvenile, adult control and type 2 diabetic donors.
We successfully sequenced and annotated more than 400 cells from child, adult control, type 1 diabetes and type 2 diabetes donors. We detect donor-type specific transcript variation. We also report that cells from child donors have less defined gene signature. Cells from type 2 diabetes donors resem...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-83139 | biostudies-arrayexpress
TranscriptomicsThe Nuclear Receptor Rev-erb alpha Regulates Adipose Tissue-Specific FGF21 Signaling (Microarray)
To investigate the role of the transcriptional repressor Rev-erb alpha in epididymal white adipose tissue, we performed a microarray analysis of gene expression in the epididymal white adipose tissue of wildtype and Rev-erb alpha knock-out mice. Examination of the transcriptome in epididymal white a...
ORGANISM(S): Mus musculus 
2016-07-20 | E-GEOD-79164 | biostudies-arrayexpress
GenomicsCistromic and epigenomic changes in Prdm16 knock-out brown adipose tissue
Prdm16 is a transcription factor that drives a complete program of brown adipocyte differentiation, but the mechanism by which Prdm16 activates gene transcription remains unknown. Utilizing ChIP-seq teqhnique, we found that Prdm16 binds to chromatin at/near many brown fat-selective genes in BAT. Int...
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-63965 | biostudies-arrayexpress
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