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TranscriptomicsTranscriptomic and metabolomic analysis of Yukon Thellungiella plants grown in cabinets and their natural habitat
Background: Thellungiella salsuginea is an important model plant due to its natural tolerance to abiotic stresses including salt, cold, and water deficits. Microarray and metabolite profiling have shown that Thellungiella undergoes stress-responsive changes in transcript and organic solute abundanc...
ORGANISM(S): Thellungiella 
2012-10-22 | E-GEOD-41182 | biostudies-arrayexpress
TranscriptomicsEthosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression
Transcriptional profiling of C. elegans strains grown in the presence and absence of ethosuximide. Two mutant alleles of dnj-14 (tm3223 and ok237) and two wild type control strains (N2 and CZ1200) were analysed. dnj-14 is the worm orthologue of the human DNAJC5 gene, mutations in which cause the neu...
ORGANISM(S): Caenorhabditis elegans 
2015-10-02 | E-MTAB-3919 | biostudies-arrayexpress
TranscriptomicsUse of clinical chromosomal microarray in Chinese patients with autism spectrum disorder - implications of a copy number variation involving dpp10 (CGX-12)
Background: Array-Comparative-Genomic-Hybridization (aCGH) is recommended as first-tier genetic test for children with autism spectrum disorder (ASD). However, result interpretation can be challenging as copy number variants (CNVs) in non-European ASD patients is not well studied. To address this li...
ORGANISM(S): Homo sapiens 
2017-04-07 | E-MTAB-5665 | biostudies-arrayexpress
TranscriptomicsUse of clinical chromosomal microarray in Chinese patients with autism spectrum disorder - implications of a copy number variation involving dpp10 (Perkin Elmer CGX)
Background Array-Comparative-Genomic-Hybridization (aCGH) is recommended as first-tier genetic test for children with autism spectrum disorder (ASD). However, result interpretation can be challenging as copy number variants (CNVs) in non-European ASD patients is not well studied. To address this lit...
ORGANISM(S): Homo sapiens 
2017-04-07 | E-MTAB-5672 | biostudies-arrayexpress
TranscriptomicsActivity of a stem cell enhancer influences stem cell programs and clinical outcome in leukaemia
Chip-chip data from primary human AML patient blasts, normal CD34+ HSCs, normal neutrophils and normal T cells with H3K9 and H3K27 antibodies. Gene expression profiling from primary human AML patient blasts and CD34+ normal cells. Analysis of the chromatin landscape of the ERG locus using H3K9 and H...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-38865 | biostudies-arrayexpress
TranscriptomicsmiR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues fro...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22058 | biostudies-arrayexpress
TranscriptomicsRNA-seq (Illumina and PacBio) of hESC
We used PacBio data to identify more reliable transcripts from hESC, based on which we can estimate gene/transcript abundance better from Illumina data. PacBio long reads and Illumina short reads were generated from the same hESC cell line H1. PacBio reads were error-corrected by Illumina reads to i...
ORGANISM(S): Homo sapiens 
2013-10-30 | E-GEOD-51861 | biostudies-arrayexpress
TranscriptomicsTargeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor (Affymetrix)
Small cell lung cancer (SCLC) is an aggressive disease with high mortality. The identification of effective pharmacological strategies to target SCLC biology represents an urgent need. Using a high-throughput cellular screen of a diverse chemical library we observe that SCLC is sensitive to transcri...
ORGANISM(S): Homo sapiens 
2014-10-23 | E-GEOD-62609 | biostudies-arrayexpress
UnknownEffects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331,288 participants.
Not available
S-EPMC4673089 | biostudies-literature
UnknownHeterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight.
Not available
S-EPMC7943191 | biostudies-literature
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