Sort   by:  
 Page size 
TranscriptomicsHeparan Sulfation Dependent FGF Signalling Maintains ES Cells Primed for Differentiation in a Heterogeneous State
Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous LIF and BMP4 perpetuate a pluripotent state, less is known about factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critical co-receptors for signals ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-15974 | biostudies-arrayexpress
TranscriptomicsRole of the hypoxia-inducible histone H3K9 methylation regulating enzymes Jmjd1a and G9a in stem cell self-renewal and tumorigenesis
Hypoxia is one of the major driving forces mediating tumor angiogenesis, aggressiveness, as well as resistance to chemo- and radiotherapy. It has also been suggested to play important roles in stem cell maintenance for both normal and cancer tissues. However, the mechanisms by which hypoxia-driven e...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-35061 | biostudies-arrayexpress
TranscriptomicsDeletion of Tardbp Down-Regulates Tbc1d1, a Gene Linked to Obesity, and Alters Body Fat Metabolism
Tat Activating Regulatory DNA Binding Protein (Tardbp or TDP-43), a highly conserved metazoan DNA/RNA binding protein thought to be involved in RNA transcription and splicing, has been linked to the pathophysiology of amyotrophic lateral sclerosis and frontotemporal lobar degeneration and is essenti...
ORGANISM(S): Mus musculus 
2010-07-15 | E-GEOD-21993 | biostudies-arrayexpress
TranscriptomicsCharacterization of the starvation response in the Arabidopsis dcl1-9 mutant
The SnRK1 protein kinase, the plant ortholog of mammalian AMPK and yeast Snf1, is activated by the energy depletion caused by adverse environmental conditions. Upon activation, SnRK1 triggers extensive transcriptional changes to restore homeostasis and promote stress tolerance and survival partly th...
ORGANISM(S): Arabidopsis thaliana 
2013-07-15 | E-GEOD-46713 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cell differentiation following treatment with DKK1
Assessed effect of DKK1 treatment on gene expression during the first four days of ES cell differentiation in serum containing medium.
ORGANISM(S): Mus musculus 
2006-12-31 | E-MEXP-759 | biostudies-arrayexpress
TranscriptomicsGraded Nodal/Activin Signaling Governs ES Cell Fate Decisions via Differential Recruitment of Phospho-Smad2 to Oct4 and Distinct Target Gene Subsets
Nodal and Activin are morphogens of the TGFbeta superfamily of signaling molecules that direct differential cell fate decisions in a dose- and distance-dependent manner. During early embryonic development the Nodal/Activin pathway is responsible for the specification of mesoderm, endoderm, node and ...
ORGANISM(S): Mus musculus 
2011-06-30 | E-GEOD-23239 | biostudies-arrayexpress
TranscriptomicsAge-dependent gene expression profiles after hepatic ischemia/reperfusion in mice
Experimental Design: 1. The goal of the experiment: Age-Dependent Gene Expression Profiles After Hepatic Ischemia/Reperfusion: Implications for the AP-1 and Ubiquitin-Proteosome Pathways 2. Brief description of the experiment: Hepatic ischemia/reperfusion (I/R) injury is a complication of liver surg...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10654 | biostudies-arrayexpress
TranscriptomicsEmbryonic stem cells exhibit mRNA isoform-specific translational regulation
Investigation of the differential translation rates of individual mRNA variants in embryonic stem cells (ESCs) and in ESC-derived neural precursor cells (NPCs) using polysome profiling coupled to RNA sequencing. Mouse ESCs were differentiated into Sox1-positive neural precursor cells (NPCs). One rep...
ORGANISM(S): Mus musculus 
2016-01-26 | E-GEOD-73467 | biostudies-arrayexpress
GenomicsChIP Seq of Oct4, Nanog, H3K27me3 in Oct4+/+ and Oct4 +/- mES cells
Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centred on the transcription factors Oct4 and Nanog. ESCs fluctuate between states of high and low Nanog expression that direct efficient or inefficient self-renewal. To date, robust self-renewing ESC states have only be...
ORGANISM(S): Mus musculus 
2013-05-07 | E-MTAB-1617 | biostudies-arrayexpress
MetabolomicsCustomized Consensus Spectral Library Building for Untargeted Quantitative Metabolomics Analysis with Data Independent Acquisition Mass Spectrometry and MetaboDIA Workflow
Data independent acquisition-mass spectrometry (DIA-MS) coupled with liquid chromatography is a promising approach for rapid, automatic sampling of MS/MS data in untargeted metabolomics. However, wide isolation windows in DIA-MS generate MS/MS spectra containing a mixed population of fragment ions t...
2018-03-26 | MTBLS417 | MetaboLights
Sort   by:  
 Page size