Sort   by:  
 Page size 
ProteomicsAregger_C12ORF49_BioID_2020_TripleTOF5600
This dataset consists of 18 raw MS files and associated peak lists and result files, acquired on AB SCIEX 5600 TripleTOF mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Michael Aregger, affinity purification and mass spectrometric acquisition was performed ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-25 | MSV000085005 | MassIVE
ProteomicsThioredoxin reduces complement factor H and alters its complement regulatory function
Complement factor H (CFH) is an enzyme responsible for inactivating components of the complement cascade, thus limiting the downstream effector mechanisms which would otherwise occur were the process to continue unregulated. In view of the close structural and functional homology between β2GPI and C...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD009558 | Pride
Complement factor h Thioredoxin Disulfide bonds 
ProteomicsNitration of Tyrosines In Complement Factor H Domains Alters Its Immunological Activity and Mediates A Pathogenic Role In Age Related Macular Degeneration
Nitrosative stress has been implicated in the pathogenesis of age related macular degeneration (AMD). Tyrosine nitration is a unique type of post translational modification that occurs in the setting of inflammation and nitrosative stress. To date, the significance and functional implications of tyr...
ORGANISM(S): Homo sapiens (Human) 
2017-08-29 | PXD005613 | Pride
Complement factor h Nitrotyrosine Cfh Macular degeneration 
ProteomicsKinome profiling of Non-Hodgkin Lymphoma identifies Tyro3 as a therapeutic target in PEL
Non-Hodgkin lymphomas (NHL) make up the majority of lymphoma diagnoses and represent a very diverse set of malignancies. We sought to identify kinases uniquely upregulated in different NHL subtypes. Using Multiplexed Inhibitor Bead-mass spectrometry (MIB/MS), we found Tyro3 was uniquely upregulated ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD012087 | Pride
Primary effusion lymphoma Tyro3 Non-hodgkin lymphoma Kinome profiling 
GenomicsGenome-wide Analysis of Transcriptional Regulators in Human Blood Stem/Progenitor Cells reveals a densely interconnected network of coding and non-coding genes.
Combinatorial transcription factor (TF) interactions regulate hematopoietic stem cell formation, maintenance and differentiation, and are increasingly recognised as drivers of stem cell signatures in cancer. However, genome-wide combinatorial binding patterns for key regulators do not exist in prim...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-GEOD-45144 | biostudies-arrayexpress
TranscriptomicsUp-regulation of IFN-related genes in BRCA2-/- cells
Microarray-based expression profiling of BRCA2 knockout and isogenic wild type HCT116 human colorectal cancer cells One way ANOVA, single factor comparison of wild type and BRCA2 knockout cells, three CEL files for wild type, three CEL files for BRCA2 knockout
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-54830 | biostudies-arrayexpress
GenomicsGlobal Transcriptome Analysis and Enhancer Landscape of Human Primary T Follicular Helper and T Effector Lymphocytes (ChIP-Seq)
T follicular helper (Tfh) cells are a subset of CD4+ T helper (Th) cells that migrate into germinal centers and promote B cell maturation into memory B and plasma cells. Tfh cells are necessary for promotion of protective humoral immunity following pathogen challenge, but when aberrantly regulated, ...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-58595 | biostudies-arrayexpress
UnknownSARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice.
Not available
S-EPMC7809486 | biostudies-literature
Transcriptomics18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.
Fluorine-18-fluoro-2-deoxy-D-glucose (FDG) is widely used as positron-emission-tomography (PET) radiotracer for the detection and staging of human cancer. Tumor uptake of FDG varies substantially between different cancer types and between patients with the same tumor type. The molecular basis for th...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-21217 | biostudies-arrayexpress
TranscriptomicsGenomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients
Anti-EGFR antibodies are effective in therapies for late-stage colorectal cancer (CRC); however, many tumours are unresponsive or develop resistance. We performed genomic analysis of intrinsic and acquired resistance to anti-EGFR therapy in prospectively collected tumour samples from 25 CRC patients...
ORGANISM(S): Homo sapiens 
2019-09-21 | E-MTAB-8340 | biostudies-arrayexpress
Sort   by:  
 Page size