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ProteomicsTo identify the nuclear partner(s) of TYRO3 in colon cells using LC-Quadrupole Time-of-Flight Mass Spectrometry.
Colorectal cancer (CRC) is one of the most common death-related cancers worldwide. Aberrant expression of oncogenes is regarded as a predominant factor in CRC development. In our study, we found that TYRO3 intracellular domain nuclear translocation promotes CRC cell proliferation, metastasis, and tu...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD029743 | Pride
Tyro3 Lc-quadrupole time-of-flight mass spectrometry Human Colon 
GenomicsExpression data from knockdown of Tyro3 in hepatocellular carcinoma
Expression data from knockdown of Tyro3 in hepatocellular carcinoma
PRJNA489091 | ENA
GenomicsKinase activity of nuclear TYRO3 promotes colon cancer malignancy
Kinase activity of nuclear TYRO3 promotes colon cancer malignancy
PRJNA778667 | ENA
GenomicsRegulated intramembrane proteolysis dependent TYRO3 signaling in melanoma cells
Regulated intramembrane proteolysis dependent TYRO3 signaling in melanoma cells
PRJNA787117 | ENA
ProteomicsKinome profiling of Non-Hodgkin Lymphoma identifies Tyro3 as a therapeutic target in PEL
Non-Hodgkin lymphomas (NHL) make up the majority of lymphoma diagnoses and represent a very diverse set of malignancies. We sought to identify kinases uniquely upregulated in different NHL subtypes. Using Multiplexed Inhibitor Bead-mass spectrometry (MIB/MS), we found Tyro3 was uniquely upregulated ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD012087 | Pride
Primary effusion lymphoma Tyro3 Non-hodgkin lymphoma Kinome profiling 
TranscriptomicsExpression data from knockdown of Tyro3 in hepatocellular carcinoma
Tyro3 is a member of the TAM (Tyro3, Axl and Mer) receptor family. In this study, we want to know potential association between Tyro3 expression in HCC and the involved signaling pathway.
ORGANISM(S): Homo sapiens 
2018-09-04 | GSE119388 | GEO
GenomicsQuantitative Analysis of the Transcriptomes of Tyro3- overexpressed and knocked out cell lines
Quantitative Analysis of the Transcriptomes of Tyro3- overexpressed and knocked out cell lines
PRJNA704690 | ENA
GenomicsKinase activity of nuclear TYRO3 promotes colon cancer malignancy
The goal of this study is to compare the different biological functions between nuclear (ICD)-TYRO3- and kinase dead (KD)-TYRO3-overexpressed cells by BRD3 occupancy profiling. We revel that ICD-TYRO3-overexpressed cell were particularly enriched in negatively regulate cell death, regulation of cell...
ORGANISM(S): Homo sapiens 
2024-11-08 | GSE188378 | GEO
TranscriptomicsQuantitative Analysis of the Transcriptomes of Tyro3- overexpressed and knocked out cell lines
The goals of this study are to compare transcriptome profiling among four different cell lines including parental cells, resistant cells, Tyro3-overexpression cells, and Tyro3 knockout cells.
ORGANISM(S): Mus musculus 
2021-07-14 | GSE167467 | GEO
TranscriptomicsRegulated intramembrane proteolysis dependent TYRO3 signaling in melanoma cells
Multi-omics examination of regulated intramembrane proteolysis (RIP) dependent TYRO3 signaling in melanoma cells.
ORGANISM(S): Homo sapiens 
2024-06-01 | GSE190431 | GEO
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