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TranscriptomicsBRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas
Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of hetero...
ORGANISM(S): Homo sapiens 
2011-03-04 | E-GEOD-27659 | biostudies-arrayexpress
TranscriptomicsWild Type Tumor Repressor Protein 53 (TRP53) Promotes Ovarian Cancer Cell survival
Loss of Pten in the KrasG12D;Amhr2-Cre mutant mice leads to the transformation of ovarian surface epithelial (OSE) cells and rapid development of low-grade, invasive serous adenocarcinomas. Tumors occur with 100% penetrance and express elevated expression of wild type tumor repressor protein 53 (TRP...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-34882 | biostudies-arrayexpress
TranscriptomicsTumor repressor protein 53 and steroid hormones provide a new paradigm for ovarian cancer metastases
The functional status of the tumor repressor protein (TP53 or TRP53) is a defining feature of ovarian cancer. Mutant or null alleles of TP53 are expressed in greater than 90% of all high-grade serous adenocarcinomas. Wild type TP53 is elevated in low-grade serous adenocarcinomas in women and in our ...
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-51095 | biostudies-arrayexpress
UnknownReal-time dynamics and cross-correlation gating spectroscopy of free-carrier Drude slow-light solitons.
Optical solitons-stable waves balancing delicately between nonlinearities and dispersive effects-have advanced the field of ultrafast optics and dynamics, with contributions spanning from supercontinuum generation to soliton fission, optical event horizons, Hawking radiation and optical rogue waves,...
S-EPMC6062241 | biostudies-literature
UnknownReal-time transition dynamics and stability of chip-scale dispersion-managed frequency microcombs.
Femtosecond mode-locked laser frequency combs have served as the cornerstone in precision spectroscopy, all-optical atomic clocks, and measurements of ultrafast dynamics. Recently frequency microcombs based on nonlinear microresonators have been examined, exhibiting remarkable precision approaching ...
S-EPMC7118405 | biostudies-literature
UnknownMitochondrial diseases in Hong Kong: prevalence, clinical characteristics and genetic landscape.

Objective

To determine the prevalence of mitochondrial diseases (MD) in Hong Kong (HK) and to evaluate the clinical characteristics and genetic landscape of MD patients in the region.

Methods

This study retrospectively reviewed the phenotypic and molecular characteristics of MD patien...
S-EPMC9979401 | biostudies-literature
UnknownThe Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clin...
S-EPMC6601620 | biostudies-literature
UnknownSurvival After Invasive or Conservative Management of Stable Coronary Disease.

Background

The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) compared an initial invasive versus an initial conservative management strategy for patients with chronic coronary disease and moderate or severe ischemia, with no maj...
S-EPMC9797439 | biostudies-literature
UnknownWound irrigation does not affect health-related quality of life after open fractures: results of a randomized controlled trial.

Aims

The Fluid Lavage in Open Fracture Wounds (FLOW) trial was a multicentre, blinded, randomized controlled trial that used a 2 × 3 factorial design to evaluate the effect of irrigation solution (soap versus normal saline) and irrigation pressure (very low versus low versus...
S-EPMC6413805 | biostudies-literature
UnknownAre large clinical trials in orthopaedic trauma justified?
BACKGROUND:The objective of this analysis is to evaluate the necessity of large clinical trials using FLOW trial data. METHODS:The FLOW pilot study and definitive trial were factorial trials evaluating the effect of different irrigation solutions and pressures on re-operation. To explore treatment e...
S-EPMC5909275 | biostudies-literature
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