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UnknownA prospective international multisite randomized controlled trial of water exchange with and without distal cap(s) in adenoma detection.

Background

Interval cancers are linked to a low adenoma detection rate (ADR), prompting calls for benchmark-guided ADR performance improvement. Although water exchange and a straight cap (CAP) have been reported to independently improve ADR, the effects of Daisycuff™ and Endocuff ...
S-EPMC12850690 | biostudies-literature
TranscriptomicsExpression data from fetal mouse lung from mothers fed high fibre or acetate
We used microarrays to detail the global programme of gene expression in the fetal lung late in gestation, from mothers that had been fed normal chow, high fibre, or acetate in the drinking water. The experiment was designed to examine the hypothesis that metabolites of the mother i.e. acetate could...
ORGANISM(S): Mus musculus 
2015-06-29 | E-GEOD-69525 | biostudies-arrayexpress
UnknownMitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy.
Mitochondria form a complex, interconnected reticulum that is maintained through coordination among biogenesis, dynamic fission, and fusion and mitophagy, which are initiated in response to various cues to maintain energetic homeostasis. These cellular events, which make up mitochondrial quality con...
S-EPMC8449344 | biostudies-literature
UnknownWhat defines response to vagus nerve stimulation in children with drug-resistant epilepsy? A prospective cohort study from the CONNECTiVOS collaboration.

Objectives

Responsiveness to vagus nerve stimulation (VNS) in children with drug-resistant epilepsy (DRE) is often defined based on reduction in seizure frequency, typically at the 50% threshold, with limited consideration to the effects of therapy on seizure severity and health-related qual...
S-EPMC12605625 | biostudies-literature
UnknownRAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.

Background

Cutaneous squamous-cell carcinomas and keratoacanthomas are common findings in patients treated with BRAF inhibitors.

Methods

We performed a molecular analysis to identify oncogenic mutations (HRAS, KRAS, NRAS, CDKN2A, and TP53) in the lesions from patients treated with the...
S-EPMC3724537 | biostudies-literature
UnknownAutogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial.
Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunotherapy designed from tumor-specific somatic mutation data obtain...
S-EPMC11750724 | biostudies-literature
UnknownParticipant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis.

Background

Precision prevention involves tailoring interventions to the unique characteristics of a group or individual to maximize their effectiveness. In this study, we examined the role of participant characteristics in the effectiveness of lifestyle interventions to optimize gestational ...
S-EPMC12552448 | biostudies-literature
UnknownParticipant characteristics in the prevention of gestational diabetes as evidence for precision medicine: a systematic review and meta-analysis.

Background

Precision prevention involves using the unique characteristics of a particular group to determine their responses to preventive interventions. This study aimed to systematically evaluate the participant characteristics associated with responses to interventions in gestational diab...
S-EPMC10551015 | biostudies-literature
UnknownEstimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.
Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score regression (LDSC) and genomic restricted maximum likelihood (GREML). The massively ...
S-EPMC5993419 | biostudies-literature
UnknownRefining the diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis.

Background

Perinatal outcomes vary for women with gestational diabetes mellitus (GDM). The precise factors beyond glycemic status that may refine GDM diagnosis remain unclear. We conducted a systematic review and meta-analysis of potential precision markers for GDM.

Methods

Systematic...
S-EPMC10728189 | biostudies-literature
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