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TranscriptomicsExpression data from a new FACS approach isolated hESC derived endoderm cells using transcription factors
We show that high quality microarray gene expression profiles can be obtained following FACS sorting of cells using combinations of transcription factors. We use this transcription factor FACS (tfFACS) methodology to perform a genomic analysis of hESC-derived endodermal lineages marked by combinatio...
ORGANISM(S): Homo sapiens 
2011-08-23 | E-GEOD-24135 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of murine granule neuron precursors and medulloblastoma
Sonic hedgehog (Shh) signals via Gli transcription factors to stimulate proliferation of granule neuron precursor cells (GNPs) in the cerebellum. Deregulation of Shh target genes often results in unrestrained GNP proliferation and eventually medulloblastoma (MB), the most common pediatric brain mali...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-17702 | biostudies-arrayexpress
TranscriptomicsMADS: a New and Improved Method for Analysis of Differential Alternative Splicing by Exon-tiling Microarrays
We describe a method, MADS (Microarray Analysis of Differential Splicing), for discovery of differential alternative splicing from exon tiling microarrays. MADS incorporates a series of low-level analysis algorithms motivated by the “probe-rich” design of exon arrays, including background correction...
ORGANISM(S): Mus musculus 
2008-05-09 | E-GEOD-11344 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiles in Oct4-knockdown and Ccna2-knockdown mouse embryos.
Gene regulation at the maternal-embryonic transition in the pre-implantation mouse embryo is not well understood. We knock down Ccna2 to establish proof-of-concept that antisense morpholino oligonucleotides can be used to target specific genes. We applied this strategy to study Oct4 and discovered...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-13981 | biostudies-arrayexpress
TranscriptomicsFoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting geneti...
ORGANISM(S): Mus musculus 
2011-03-16 | E-GEOD-27932 | biostudies-arrayexpress
ProteomicsIdentification of candidate microRNA biomarkers of endometriosis in different bodily fluids
Endometriosis is a common gynecological condition that affects approximately 10% of women of reproductive age and up to half of those experiencing infertility. However, there is a lack of reliable noninvasive diagnostic tools for diagnosing endometriosis. This study aims to identify novel biomarkers...
ORGANISM(S): Homo Sapiens 
2025-11-17 | PXD070868 |
UnknownBlood pressure loci identified with a gene-centric array.
Not available
S-EPMC3234370 | biostudies-literature
UnknownGenome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.
Not available
S-EPMC10790310 | biostudies-literature
UnknownDe novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Not available
S-EPMC7007577 | biostudies-literature
UnknownLapses in Care Among Patients Assigned to Ranibizumab for Proliferative Diabetic Retinopathy: A Post Hoc Analysis of a Randomized Clinical Trial.
Not available
S-EPMC8532036 | biostudies-literature
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