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TranscriptomicsThe RNA-binding protein HuR coordinates global changes in gene expression during patterning of early peripheral nerves
Identify mRNA targets of the RNA-binding protein HuR in vivo during Schwann cell development using RIP-chip analysis. IP protocol of endogenous mRNA-transfected HuR complexes was performed as described in Keene et al. (2006). In brief, 500 mg of whole-cell lysate obtained from a pool of NB or P5 sci...
ORGANISM(S): Mus musculus 
2012-01-19 | E-MEXP-3519 | biostudies-arrayexpress
GenomicsDNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Bisulfite-Seq2]
DNA methylation is a key epigenetic regulator of mammalian embryogenesis and somatic cell differentiation. Using high-resolution genome-scale maps of methylation patterns, we show that the formation of myelin in the peripheral nervous system, proceeds with progressive DNA demethylation, which coinci...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-51031 | biostudies-arrayexpress
GenomicsDNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Bisulfite-Seq]
DNA methylation is a key epigenetic regulator of mammalian embryogenesis and somatic cell differentiation. Using high-resolution genome-scale maps of methylation patterns, we show that the formation of myelin in the peripheral nervous system, proceeds with progressive DNA demethylation, which coinci...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-45343 | biostudies-arrayexpress
TranscriptomicsDNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Gene Expression Array: C57Bl6J mice]
DNA methylation is a key epigenetic regulator of mammalian embryogenesis and somatic cell differentiation. Using high-resolution genome-scale maps of methylation patterns, we show that the formation of myelin in the peripheral nervous system, proceeds with progressive DNA demethylation, which coinci...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-45700 | biostudies-arrayexpress
TranscriptomicsDNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Gene Expression Array: GNMT mice]
DNA methylation is a key epigenetic regulator of mammalian embryogenesis and somatic cell differentiation. Using high-resolution genome-scale maps of methylation patterns, we show that the formation of myelin in the peripheral nervous system, proceeds with progressive DNA demethylation, which coinci...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-45701 | biostudies-arrayexpress
Transcriptomicsc-JUN REPROGRAMS SCHWANN CELLS OF INJURED NERVES TO GENERATE A REPAIR CELL ESSENTIAL FOR REGENERATION
The striking PNS regenerative response to injury rests on the plasticity of adult Schwann cells and their ability to transit between differentiation states, a highly unusual feature in mammals. Using mice with inactivation of Schwann cell c-Jun, we show that the injury response involves c-Jun depen...
ORGANISM(S): Mus musculus 
2012-06-13 | E-GEOD-38693 | biostudies-arrayexpress
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