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ProteomicsRetina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Net-works after Optic Nerve Crush in a Rat Model of Surgical Menopause. Katalin Prokai-Tatrai, Khadiza Zaman, Ammar Kapic, Kelleigh Hogan , Gabriela Sanchez-Rodriguez, Anna E. Silverio Vien Nguyen , Laszlo Prokai and Andrew J. Feola
The association between 17β-estradiol (E2) deprivation, seen in menopause and a risk for devel-oping glaucoma, has been shown. Thus, exogenous supplementation of E2 may protect against retinal ganglion cell (RGC) degradation and vision loss. Here, we investigated the utility of topical 10β,17β-dihyd...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-07 | PXD059520 | Pride
Bioinformatics  dhed  estrogen  glaucoma  menopause  optic nerve crush  optomotor response  protein–protein interaction networks  quantitative label-free retina proteomics 
Genomicsena-DATASET-MPIMG-04-05-2016-11:01:24:124-96 - samples
RNAseq on Illumina HiSeq2000/2500 of WNT reporter of PDO culture derived from colorectal cancer metastasis sample
EGAD00001002074 | EGA
GenomicsDAC for Cardiac Translatomes of 80 Human Samples (65 DCM cases 15 controls)
Data Access Committee EGAC00001001040
EGAC00001001040 | EGA
GenomicsDissection of the molecular complexity of colorectal cancer in pre-clinical models identifies predictive signatures of sensitivity to EGFR inhibitors
Colorectal carcinoma (CRC) is a heterogeneous tumour entity, with only a fraction of the tumours responding to currently available therapies. A detailed understanding of the biology and genetics of CRC is a prerequisite for precision medicine. To address this challenge in clinical oncology, the Onco...
EGAS00001001752 | EGA
GenomicsOncotrack DAC
Data Access Committee EGAC00001000469
EGAC00001000469 | EGA
Genomicsena-DATASET-MPIMG-15-06-2017-11:16:33:021-1359 - samples
RNAseq on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from colorectal cancer metastasis sample (OT2_cohort)
EGAD00001003366 | EGA
Genomicsena-DATASET-MPIMG-15-06-2017-11:23:09:087-1369 - samples
Whole-genome sequencing on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from colorectal cancer primary tumor sample (OT2_cohort)
EGAD00001003376 | EGA
Genomicsena-DATASET-MPIMG-15-06-2017-11:26:46:865-1376 - samples
Whole-exome sequencing on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from colorectal cancer primary tumor sample (OT2_cohort)
EGAD00001003384 | EGA
Genomicsena-DATASET-MPIMG-15-06-2017-11:21:44:409-1366 - samples
Whole-genome sequencing on Illumina HiSeq2000/2500 of PDO culture derived from colorectal cancer metastasis sample (OT2_cohort)
EGAD00001003373 | EGA
Genomicsena-DATASET-MPIMG-15-06-2017-11:22:40:413-1368 - samples
Whole-genome sequencing on Illumina HiSeq2000/2500 of colorectal cancer primary tumor sample (OT2_cohort)
EGAD00001003375 | EGA
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