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GenomicsHistone H3, lysine 27 acetylation ChIP-seq in NALM6 expressing ETV6-RUNX1
ETV6-RUNX1 is a fusion protein bringing together almost the entire coding sequence of RUNX1, including the DNA binding runt domain, and the N-terminus of ETV6 which is known to include transcriptional repressors including histone deacetylation 3 (HDAC3). Here we perform ChIP-seq for the active chrom...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12207 | biostudies-arrayexpress
GenomicsChIP-seq in the cell line NALM-6 for RUNX1 and ETV6-RUNX1 to assess competition between the two proteins for DNA binding
RUNX1 and ETV6-RUNX1 possess the same DNA-binding runt domain and are therefore expected to bind to canonical RUNX motifs. As the ETV6-RUNX1 fusion arises in the context of native RUNX1 expression, and since RUNX1 is retained or amplified in B-ALL, the two proteins are likely to compete for the same...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12209 | biostudies-arrayexpress
TranscriptomicsInvestigation of placental gene expression in obese women exposed to Metformin during pregnancy
Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determin...
ORGANISM(S): Homo sapiens 
2019-01-31 | E-MTAB-6418 | biostudies-arrayexpress
TranscriptomicsInvestigation of placental DNA methylation in obese women exposed to Metformin during pregnancy
Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determin...
ORGANISM(S): Homo sapiens 
2018-11-01 | E-MTAB-6421 | biostudies-arrayexpress
UnknownA community-wide media campaign to promote walking in a Missouri town.
Not available
S-EPMC1432093 | biostudies-literature
UnknownOn the structure of the N-terminal domain of the MscL channel: helical bundle or membrane interface.
Not available
S-EPMC2517020 | biostudies-literature
TranscriptomicsGenetics of gene expression responses to temperature stress in a sea urchin gene network (HTS)
Stress responses play an important role in shaping species distributions and robustness to climate change. We investigated how stress responses alter the contribution of additive genetic variation to gene expression during development of the purple sea urchin, Strongylocentrotus purpuratus, under in...
ORGANISM(S): Strongylocentrotus purpuratus 
2012-11-30 | E-GEOD-38606 | biostudies-arrayexpress
GenomicsChIP-seq for RUNX1 and ETV6-RUNX1 in an induced pluripotent stem cell model of ETV6-RUNX1 pre-leukaemia
ETV6-RUNX1 is a first-hit mutation in childhood B cell precursor acute lymphoblastic leukaemia. ETV6-RUNX1 is a fusion protein which inherits the DNA-binding runt domain from RUNX1. Here we performed chromatin precipitation for native RUNX1 and ETV6-RUNX1 using RUNX1 antibodies and specifically for ...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12208 | biostudies-arrayexpress
TranscriptomicsDNA modification study in major depressive disorder
Major depressive disorder (MDD) exhibits numerous clinical, epidemiological, and molecular features that are consistent with partially inherited and partially acquired epigenetic misregulation. We performed microarray based DNA modification study of MDD, utilizing affected and unaffected samples fro...
ORGANISM(S): Homo sapiens 
2012-04-27 | E-GEOD-37579 | biostudies-arrayexpress
UnknownProline 35 of human immunodeficiency virus type 1 (HIV-1) Vpr regulates the integrity of the N-terminal helix and the incorporation of Vpr into virus particles and supports the replication of R5-tropic HIV-1 in human lymphoid tissue ex vivo.
Not available
S-EPMC1951402 | biostudies-literature
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