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ProteomicsA transient protein folding response targets aggregation in the early phase of TDP-43-mediated disease
Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we generated a longitudinal quantitative proteomic map of the cortex from the cytoplasmic TDP-43 rNLS8 mouse model of ALS and FTLD ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-31 | PXD042382 | Pride
Ftld Longitudinal Als Cortex Mouse Proteinopathy Motor neuron disease Mnd Tdp-43 Lc-ms/ms Tandem mass tagging Amyotrophic lateral sclerosis Frontotemporal dementia Ftd Frontotemporal lobar degeneration 
UnknownFactors associated with the uptake of clinical breast examination for early detection of breast cancer: interaction analysis of the 2022 Tanzania Demographic and Health Survey and Malaria Indicator Survey.
Not available
S-EPMC12718559 | biostudies-literature
UnknownLongitudinal follow-up by MR angiography reveals progressive dilatation of the distal aorta after aortic root replacement in Marfan syndrome.
Not available
S-EPMC10511572 | biostudies-literature
MetabolomicsThe impact of nutritional supplementation on sweat metabolomic content
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
2021-03-15 | MTBLS2427 | MetaboLights
UnknownCluster analysis of 100 Marfan patients based on aortic 4D flow MRI and Z-score: insights into disease heterogeneity and stratification of subgroups.
Not available
S-EPMC11913908 | biostudies-literature
TranscriptomicsTranscripts differentially expressed in healthy blood mDCs compared to healthy monocytes
To directly compare the SLE monocyte transcriptional program with that of blood mDC precursors, we purified lineage HLA-DRhighCD11chigh mDCs and CD14+ monocytes from the blood of five healthy donors. Their gene expression profiles were then compared to those of blood SLE monocytes. An unsupervised c...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46913 | biostudies-arrayexpress
UnknownAntibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab.
Not available
S-EPMC8927425 | biostudies-literature
TranscriptomicsHighly Recurrent MYD88 Mutations That Promote Human Lymphoma Cell Survival
The ABC subtype of diffuse large B cell lymphoma (DLBCL) remains the least curable form of this lymphoma despite recent advances in therapy. We have combined structural and functional genomics to triangulate on new oncogenic mechanisms and devise new therapeutic strategies. RNA interference screen r...
ORGANISM(S): Homo sapiens 
2010-12-30 | E-GEOD-22900 | biostudies-arrayexpress
UnknownGenetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
Not available
S-EPMC4735748 | biostudies-literature
UnknownMeasurement of the differential cross section for top quark pair production in pp collisions at [Formula: see text].
Not available
S-EPMC4657759 | biostudies-literature
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